Antidyskinetic Treatment with MTEP Affects Multiple Molecular Pathways in the Parkinsonian Striatum
Effect of MTEP on the AIM scores. 14 days’ use of MTEP significantly reduced AIM scores. At the 2nd, 5th, 12th, and 14th days, a total AIM score was calculated as the sum of the basic scores multiplied by the amplitude of the score for each AIM subtype: limb, orolingual, and axial, excluding the rotation subtype. (a) Time course of the total scores; sum of the axial, limb, and orolingual subtype scores; (b) time course of changes in the axial scores; (c) time course of changes in the limb score; and (d) time course of changes in the orolingual score. In each testing session, the AIM scores were rated following the administration of the drugs. Data are presented as the mean ± SD. versus the LID group (Kruskal-Wallis test followed by Dunn’s test for multiple comparisons or Mann–Whitney test).
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