Antidyskinetic Treatment with MTEP Affects Multiple Molecular Pathways in the Parkinsonian Striatum
mRNA level of prodynorphin (a) and proenkephalin (b). MTEP reduced prodynorphin and proenkephalin mRNA levels in the striatum of dyskinetic rats. Striatal prodynorphin and proenkephalin mRNA expression levels were determined by real-time PCR. Increased levels of the two genes were found in LID rats. There is a minor but significant () drop in the prodynorphin in the PD group. The antagonist of mGluR5 decreased the mRNA expression level in both prodynorphin and proenkephalin (one-way ANOVA, per group).
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.