Clinical Study
Rivastigmine as a Symptomatic Treatment for Apathy in Parkinson’s Dementia Complex: New Aspects for This Riddle
Table 5
12-month NPI results. In the first and third rows it has been reported the within group comparison with baseline and with 6-month results.
| Subitems NPI | Number of patients/48 (%) within groups (12 months versus baseline) (12 months versus 6 months) | Frequency × severity | Caregiver distress within groups (12 months versus baseline) (12 months versus 6 months) |
| Hallucinations | 15 (31%) () (NS) | 2 | 1 (NS) (NS) |
| Delusions | 8 (17%) () (NS) | 1 | 1 (NS) (NS) |
| Agitation/aggression | 3 (8%) (NS) (NS) | 2 | 1 (NS) (NS) |
| Dysphoria/depression | 19 (40%) () (NS) | 3 | 1 () (NS) |
| Anxiety | 21 (44%) () (NS) | 4 | 1 () (NS) |
| Irritability | 1 (2%) () () | 3 | 1 () (NS) |
| Disinhibition | 0 (0%) () () | 0 | 1 () (NS) |
| Euphoria | 0 (0%) () () | 0 | 1 () (NS) |
| Apathy | 33 (69%) () (NS) | 8 | 8 (NS) (NS) |
| Aberrant motor behavior | 1 (4%) (NS) (NS) | 1 | 1 () (NS) |
| Sleep behavior change | 5 (10%) () (NS) | 3 | 2 () (NS) |
| Appetite change | 1 (2%) () (NS) | 1 | 1 () (NS) |
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