Clinical Study
Twice-Daily versus Once-Daily Pramipexole Extended Release Dosage Regimens in Parkinson’s Disease
| | | Baseline | Once-daily | Twice-daily |
| | Adverse events (%) | 36 (81.8) | 36 (81.8) | 37 (84.1) | | Constipation | 23 (52.3) | 24 (54.5) | 20 (45.5) | | Dry mouth | 19 (43.2) | 20 (45.5) | 22 (50.0) | | Somnolence | 11 (25.0) | 12 (27.3) | 11 (25.0) | | Dizziness | 9 (20.5) | 8 (18.2) | 8 (18.2) | | Fatigue | 8 (18.2) | 8 (18.2) | 9 (20.5) | | Dyspepsia | 7 (15.9) | 8 (18.2) | 10 (22.7) | | Nausea | 7 (15.9) | 6 (13.6) | 7 (15.9) | | Edema | 5 (11.4) | 7 (15.9) | 9 (20.5) | | Hallucination | 3 (6.8) | 2 (4.5) | 5 (11.4) | | Headache | 2 (4.5) | 2 (4.5) | 1 (2.3) | | Others | 2 (4.5) | 0 (0.0) | 0 (0.0) |
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