Dual-Task Performance in GBA Parkinson’s Disease

Table 1

Demographics and clinical characteristics.

	GBA-PD	iPD	value
Demographics
Male (female) []	9 (2)	9 (2)	1.00
Age [years]	58 (41–70)	62 (41–70)	0.51
Age of onset [years]	50 (28–65)	54 (36–62)	0.22
Disease duration [years]	6 (4–13)	6 (3–10)	0.46
Levodopa dose equivalent	700 (100–1500)	400 (80–800)	0.27
Motor function
UPDRS-III (0–108)	35 (24–55)	27 (6–51)	0.01
Nonmotor function
MoCA (0–30)	25 (11–29)	28 (23–30)	0.06
TMT A [s]	45 (30–263)	37 (25–66)	0.31
TMT B [s]	95 (47–300)	86 (50–300)	0.37
ΔTMT [s]	44 (16–98)	39 (24–234)	0.89
BDI-II (0–63)	9 (5–27)	9 (1–31)	0.49

Mann-Whitney test. Values are given in median (range). Significance level was set at . UPDRS-III = Unified Parkinson’s disease rating scale, part III motor score; MoCA = Montreal Cognitive Assessment; TMT = Trail Making Test; ΔTMT = TMT B − TMT A; BDI-II = revised version of the Becks Depression Inventory; GBA-PD = Parkinson’s disease patients carrying a heterozygous glucocerebrosidase mutation; iPD = idiopathic Parkinson’s disease.