Microarray Analysis of the Molecular Mechanism Involved in Parkinson’s Disease

Table 1

List of top 10 differentially expressed genes with higher degrees in protein-protein interaction network.

Gene	Full name	Description	Degree
MAPK14	Mitogen-activated protein kinase 14	Down	68
ESR1	Estrogen receptor 1	Up	54
PTEN	Phosphatase and tensin homolog	Down	52
MTOR	Mechanistic target of rapamycin	Up	40
ATM	ATM serine/threonine kinase	Up	35
ICAM1	Intercellular adhesion molecule 1	Down	33
CD40	CD40 molecule	Up	32
AURKA	Aurora kinase A	Down	31
PRKDC	Protein kinase, DNA-activated, catalytic polypeptide	Down	29
TK2	Thymidine kinase 2, mitochondrial	Up	29

Degree was used for describing the importance of protein nodes in network. The higher the degree was, the more important the nodes were in network.