Parkinson’s Disease

Review Article

A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson’s Disease

Table 1

The characteristics of the related phenotypes data updated in all publications included.


Year, first author	NOS	Country	Groups	n	Family history	AAO	UPDRS-III	H-Y	Dementia	Depression	Orthostatic hypotension	Wearing-off	Motor fluctuation	Freezing

2017, Cilia et.al. [25]	8	Italy	GBA + PD	123	38	52.4 ± 10.2	33.5 ± 14.2	—	25 (93)	—	12 (65)	—	48 (82)	28 (92)
2017, Cilia et.al. [25]	8	Italy	GBA − PD	2641	446	57.4 ± 10.6	30.4 ± 13.7	—	240 (1254)	—	89 (840)	—	726 (168)	332 (1210)
2017, Davis et.al. [26]	7	American	GBA + PD	27	—	62.0 ± 9.0	31.8 ± 10.6	—	9	—	—	—	—	—
2017, Davis et.al. [26]	7	American	GBA − PD	675	—	68.4 ± 8.6	27.5 ± 12.9	—	58	—	—	—	—	—
2016, Thaler et al. [27]	7	Israel	GBA + PD	12	—	51.4 ± 10.7	28.8 ± 9.6	2.9 ± 0.6	—	—	—	—	—	—
2016, Thaler et al. [27]	7	Israel	GBA − PD	12	—	58.7 ± 5.7	21.7 ± 6.5	2.1 ± 0.7	—	—	—	—	—	—
2016, Swan et al. [28]	7	Israel	GBA + PD	31	—	57.0 ± 12.7	16.7 ± 8.7	2.3 ± 1.1	—	10	—	—	—	—
2016, Swan et al. [28]	7	Israel	GBA − PD	55	—	59.7 ± 11.4	20.4 ± 13.2	2.2 ± 0.9	—	7	—	—	—	—
2016, Dan et al. [29]	8	China	GBA + PD	40	—	—	—	—	—	16	—	—	—	—
2016, Dan et al. [29]	8	China	GBA − PD	1007	—	—	—	—	—	191	—	—	—	—
2015, Gan-Or et al. [24]	7	Israel	GBA + PD	19	—	—	—	—	—	—	—	—	—	—
2015, Gan-Or et al. [24]	7	Israel	GBA − PD	101	—	—	—	—	—	—	—	—	—	—
2014, Brockmann et al. [22]	7	Germany	GBA + PD	33	—	—	—	2.7 ± 0.7	—	—	—	—	—	—
2014, Brockmann et al. [22]	7	Germany	GBA − PD	26	—	—	—	2.5 ± 0.7	—	—	—	—	—	—
2014, Wang et al. [30]^#	8	China	GBA + PD	49	—	—	—	—	—	28 (49)	9 (34)	11 (37)	5 (37)	—
2014, Wang et al. [30]^#	8	China	GBA − PD	1366	—	—	—	—	—	583 (1366)	221 (843)	169 (922)	90 (924)	—
2014, Malec-Litwinowicz et.al. [31]^#	7	Poland	GBA + PD	5	—	—	—	—	—	4	1	—	—	—
2014, Malec-Litwinowicz et.al. [31]^#	7	Poland	GBA − PD	117	—	—	—	—	—	43	21	—	—	—
2014, Li et al. [32]^#	7	Japan	GBA + PD	34	—	—	—	—	—	—	5	20	—	—
2014, Li et al. [32]^#	7	Japan	GBA − PD	113	—	—	—	—	—	—	21	49	—	—
2014, Pulkes et al. [33]^#	7	China, Thailand	GBA + PD	17	—	—	—	—	—	—	—	8	—	2
2014, Pulkes et al. [33]^#	7	China, Thailand	GBA − PD	191	—	—	—	—	—	—	—	82	—	21
2013, Kumar et al. [34]^#	7	Serbia	GBA + PD	21	—	—	—	—	—	—	—	—	—	0 (19)
2013, Kumar et al. [34]^#	7	Serbia	GBA − PD	339	—	—	—	—	—	—	—	—	—	8 (287)
2011, Lesage et al. [35]^#	8	Europeans	GBA + PD	100	—	—	—	—	—	—	—	—	47 (76)	—
2011, Lesage et al. [35]^#	8	Europeans	GBA − PD	1291	—	—	—	—	—	—	—	—	532 (902)	—
2008, Gan-Or et al. [36]^#	7	Israel	GBA + PD	71	—	—	—	—	—	6	—	—	—	—
2008, Gan-Or et al. [36]^#	7	Israel	GBA − PD	283	—	—	—	—	—	28 (280)	—	—	—	—

Abbreviations: publications newly updated; ^#publications previously included, and this table only exhibits the updated clinical data in the previous publications included; other clinical features were shown in the published manuscript [11]. PD, Parkinson’s disease; GBA + PD, PD with GBA mutations; GBA − PD, PD without GBA mutations; AAO, age at onset; UPSRS-III, the Part III of Unified Parkinson Disease Rating Scale; H-Y, Hoehn–Yahr Rating Scale. AAO, UPDRS-III, and H-Y were presented as mean and standard deviation; others were shown as count data. n, total number of patients whose clinical information was available in each group.