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Parkinson’s Disease
Volume 2018, Article ID 3418306, 7 pages
https://doi.org/10.1155/2018/3418306
Research Article

The Association between LRRK2 G2385R and Phenotype of Parkinson’s Disease in Asian Population: A Meta-Analysis of Comparative Studies

1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
2Department of Neurology, Shaanxi Provincial People’s Hospital, Third Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an, Shaanxi 710068, China
3Pediatric Department, The Second People’s Hospital of Longgang District, Shenzhen, Guangdong 518112, China
4Xi’an Medical College, Xi’an, Shaanxi 710068, China

Correspondence should be addressed to Hua Lv; moc.621@3112hvl

Received 15 January 2018; Revised 20 March 2018; Accepted 15 April 2018; Published 10 July 2018

Academic Editor: Cristine Alves da Costa

Copyright © 2018 Wei Di et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Numerous studies have investigated the relationship between the LRRK2 G2385R variant and clinical characteristics in Parkinson’s disease (PD), but the results have been inconsistent. This study investigated whether the LRRK2 G2385R variant was associated with a unique clinical phenotype of PD in the Asian population, using a meta-analysis. The PubMed, Web of Science, EMBASE, CNKI, and WANFANG databases were searched until September 2017. The strict selection criteria and exclusion criteria were determined, and mean differences (MD) or odds ratios (OR) with 95% confidence intervals (CI) were used to assess the strength of associations. Statistical analyses and graphics were performed using Review Manager 5.3. Sixteen related case-control studies were included in the meta-analysis. The LRRK2 G2385R carriers significantly more often presented a family history (OR: 1.98; 95% CI: 1.16−3.39; ) and had a longer disease duration (MD = 0.47, 95% CI: 0.01−0.93, ) and a higher MMSE score (MD = 1.02, 95% CI: 0.43–1.62 ) than LRRK2 G2385R noncarriers. There were no significant differences in sex distribution, age at onset, initial symptoms, motor symptoms, depression, levodopa-equivalent dose, and related complications between LRRK2 G2385R-carrier and LRRK2 G2385R-noncarrier PD patients. Our results suggested that most of the clinical characteristics of PD patients with LRRK2 G2385R mutations are similar to those of LRRK2 G2385R noncarriers among Asian PD patients, except for the more common family history, relatively longer disease duration, and higher MMSE scores in the former group.