Research Article

CLOCK 3111T/C Variant Correlates with Motor Fluctuation and Sleep Disorders in Chinese Patients with Parkinson’s Disease

Table 2

Binary logistic regression of association between motor fluctuation and CLOCK 3111T/C variant.

VariableOR95% CI value

3111T/C variant1.0801.057–1.1040.000a
Age (years)0.6450.202–2.0670.461
Gender0.9620.649–1.4240.845
Disease duration (years)1.6560.508–5.3950.403
Hoehn-Yahr stage0.9400.885–0.9980.044b
UPDRS II + III4.6982.868–7.6950.000a
L-dopa therapy duration (year)0.8840.885–0.9980.440
L-dopa therapy initial dosage (mg/day)1.1790.961–1.5580.115
Response to levodopa0.8840.780–1.0020.053
Mean PIGD score1.0020.945–1.0620.957
EOPD0.9110.662–1.2520.565

UPDRS: Unified Parkinson’s Disease Rating Scale; MMSE: Mini-Mental State Examination; EOPD: early-onset PD. a and b.