Research Article
CLOCK 3111T/C Variant Correlates with Motor Fluctuation and Sleep Disorders in Chinese Patients with Parkinson’s Disease
Table 2
Binary logistic regression of association between motor fluctuation and CLOCK 3111T/C variant.
| Variable | OR | 95% CI | value |
| 3111T/C variant | 1.080 | 1.057–1.104 | 0.000a | Age (years) | 0.645 | 0.202–2.067 | 0.461 | Gender | 0.962 | 0.649–1.424 | 0.845 | Disease duration (years) | 1.656 | 0.508–5.395 | 0.403 | Hoehn-Yahr stage | 0.940 | 0.885–0.998 | 0.044b | UPDRS II + III | 4.698 | 2.868–7.695 | 0.000a | L-dopa therapy duration (year) | 0.884 | 0.885–0.998 | 0.440 | L-dopa therapy initial dosage (mg/day) | 1.179 | 0.961–1.558 | 0.115 | Response to levodopa | 0.884 | 0.780–1.002 | 0.053 | Mean PIGD score | 1.002 | 0.945–1.062 | 0.957 | EOPD | 0.911 | 0.662–1.252 | 0.565 |
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UPDRS: Unified Parkinson’s Disease Rating Scale; MMSE: Mini-Mental State Examination; EOPD: early-onset PD. a and b. |