Serum Homocysteine Level in Parkinson’s Disease and Its Association with Duration, Cardinal Manifestation, and Severity of Disease

Table 4

Frequency of different clinical features of Parkinson’s disease based on serum levels of homocysteine.

Serum homocysteine level (mol/L)	Parkinson’s disease features				value
	Duration of the disease (years)
	≤5	5–10	>10
≤20	57 (87/7%)	21 (77/8%)	7 (87/5%)		0.572
>20	8 (12.3%)	6 (22.2%)	11 (12.5%)
	Cardinal manifestation of the disease
	Postural instability	Tremor	Rigidity	Bradykinesia
≤20	2 (66.7%)	53 (85.5%)	11 (84/6%)	19 (86.4%)	0.841
>20	1 (33.3%)	9(14.5%)	2 (15.4%)	3 (13.6%)
	Severity of the disease based on modified Hoehn and Yahr staging
	1-2 (mild)	2.5-3 (moderate)	>3 (severe)
≤20	33 (94.3%)	36 (81.8%)	16 (76.2%)		0.154
>20	2 (5.7 %)	8 (18.2%)	5 (23.8%)