The Parkinson’s Disease Composite Scale Is Adequately Responsive to Acute Levodopa Challenge
Table 1
Baseline characteristics of the study population.
Mean or count
Standard deviation or percentage
Median
25th percentile
75th percentile
Age (years)
66.0
9.7
66
60
74
Disease duration (years)
4.7
4.5
4
1
7
Levodopa duration (years)
4.7
4.3
4
1
7
Sex
Males
53
53.0%
Females
47
47.0%
Handedness
Right
96
96.0%
Left
4
4.0%
Dominant side
Right
33
37.5%
Left
55
62.5%
BMI (kg/m2)
26.3
5.4
26.4
23.3
29.4
Education (years)
12.4
3.2
12
11
15
Disease type
Tremor-dominant PD
24
24.0%
Rigid-akinetic PD
35
35.0%
Mixed PD
24
24.0%
Non-PD (other parkinsonian syndromes)
17
17.0%
De novo
No
75
75.0%
Yes
25
25.0%
Hoehn and Yahr stage
Mild (1 and 2)
49
49.0%
Moderate (3)
23
23.0%
Severe (4 and 5)
28
28.0%
MDS-UPDRS I. nM-EDL
14.2
7.4
15
7
19
MDS-UPDRS II. M-EDL
17.5
8.9
16
10
24
MDS-UPDRS III. ME
35.3
16.0
37
22
47
MDS-UPDRS IV. MC
5.0
4.0
4
2
7
MDS-UPDRS total score
71.9
28.9
72
48
93
PDCS motor score
13.4
6.3
13
10
18
PDCS nonmotor score
9.3
6.1
10
3
14
PDCS treatment-related complications score
5.5
3.9
4
2
9
PDCS disability score
2.4
1.9
2
1
4
PDCS total score
28.2
13.3
26
18
37
CISI total score
8.7
3.5
9
6
11
PDQ-39 summary index
29.1
16.5
30
16
41
MADRS total score
13.8
7.6
14
19
8
PAS total score
14.1
7.2
14
19
9
LARS total score
−21.1
10.9
−24
−16
−28
MoCA total score
22.4
5.5
24
27
18
PDSS-2 total score
19.9
11.8
19
28
10
NMSS I. Cardiovascular problems
3.9
4.3
2
8
0
NMSS II. Sleep problems
12.2
9.2
12
20
4
NMSS III. Mood problems
12.0
14.0
6
21
2
NMSS IV. Hallucinations
1.0
2.8
0
0
0
NMSS V. Memory problems
4.3
5.3
2
7
0
NMSS VI. Gastrointestinal problems
4.7
6.0
2
8
0
NMSS VII. Urinary problems
11.0
10.8
8
20
2
NMSS VIII. Sexual problems
0.8
2.3
0
0
0
NMSS IX. Miscellaneous
4.2
6.4
2
7
0
NMSS total score
54.1
39.6
49
82
20
BMI = body mass index; CISI = Clinical Impression of Severity Index; LARS = Lille Apathy Rating Scale; MADRS = Montgomery–Asberg Depression Rating Scale; MDS-UPDRS = Movement Disorder Society-sponsored Unified Parkinson’s Disease Rating Scale; MDS-UPDRS I. nM-EDL = nonmotor experiences of daily living (Part I of MDS-UPDRS); MDS-UPDRS II. M-EDL = motor experiences of daily living (Part II of MDS-UPDRS); MDS-UPDRS III. ME = motor examination (Part III of MDS-UPDRS); MDS-UPDRS IV. MC = motor complication (Part IV of MDS-UPDRS); MoCA = Montreal Cognitive Assessment; NMSS = Non-Motor Symptoms Scale; PAS = Parkinson Anxiety Scale; PD = Parkinson’s disease; PDCS = Parkinson’s Disease Composite Scale; PDSS-2 = Parkinson’s Disease Sleep Scale 2nd version; PDQ-39 = 39-item Parkinson’s Disease Questionnaire.
