The Association between DRD3 Ser9Gly Polymorphism and Depression Severity in Parkinson’s Disease

Table 3

Groups × genes ANOVA of ALFF.

Brain region	Peak MNI coordinates (mm)			Peak F value	Clusters size (mm^3)
Main effect of groups
Right inferior occipital gyrus/lingual gyrus/fusiform gyrus	36	−90	−21	23.44	1377
Main effect of genotypes
None
Groups × genotypes interaction
Right medial frontal gyrus	6	33	42	23.02	486

Two-way factorial analysis of covariance (ANCOVA: groups × genotypes; groups: PD and HC, genotypes: Ser/Ser carriers and the Gly carriers) was performed, adjusting for age, gender, and education. A corrected threshold by Monte Carlo simulation was set at ; Abbreviations: PD, Parkinson’s disease; HC, healthy control; ALFF, amplitude of low-frequency fluctuations; MNI, Montreal Neurological Institute.