Review Article
Parkinson’s Disease in Central Asian and Transcaucasian Countries: A Review of Epidemiology, Genetics, Clinical Characteristics, and Access to Care
Table 2
PD genetic studies in Central Asian countries.
| n | Genetic mutations studied | Analysis method | Results | Sample size | Country (reference) |
| 1 | SNCA gene (Ala30Pro, Ala53Thr, Gly46Lis, Gly51Asp) | PCR, gel electrophoresis | No pathogenic mutations found | 34 PD cases | Kazakhstan [6] | 2 | GIGYF2 | PCR, Sanger sequencing | No pathogenic mutations found | Not stated | Kazakhstan [14] | 3 | SNCA (Ala53Thr), Parkin (T240M), LRRK2 (G2019S), Nat2, GSTT1, and GSTM1 | PCR, Sanger sequencing | G2019S was found in 5.7% of idiopathic PD and 17.6% of familial PD patients | 153 PD cases, 80 controls | Uzbekistan [15] | 4 | SNCA, Parkin | Not stated | 13 (19.4%) positive to SNCA gene mutation, 27 (40.3%) positive to Parkin mutation | 67 | Uzbekistan [16] |
|
|
PCR, polymerase chain reaction; PD, Parkinson’s disease.
|