Improvement of Subthalamic Nucleus Deep Brain Stimulation in Sleeping Symptoms in Parkinson’s Disease: A Meta-Analysis

Table 1

Characteristics of the eligible studies.

Author	Year	N	Age	Disease duration	DBS programming	Scale	Follow-up	Preoperative score	Preoperative LE	Postoperative score	Postoperative LE
Klepitskaya et al. [24]	2018	22	58.3 ± 7.4	10.2 ± 4.9	STN-DBS	IRLSSG criteria	6 months	19.59 ± 6.95	1203.2 ± 657.5	14.53 ± 12.27	370.8 ± 69.2
Kedia et al. [18]	2004	11	61	14.2	STN-DBS	IRLSSG criteria	6 months	15 ± 5.9	1169.4 ± 702.7	4.3 ± 3.1	294.0 ± 384.3
Chahine et al. [16]	2011	6	62 ± 8.8	13.1 ± 8	STN-DBS	IRLSSG criteria	6 months	23.0 ± 5.8	1193.8 ± 600.7	13.8 ± 8.6	599.6 ± 369.7
Driver-Dunckley et al. [17]	2006	6	65.1 ± 10.3	13.7 ± 3.1	STN-DBS	IRLSSG criteria	3 months	24.8 ± 8.3	1591.5 ± 536.3	4 ± 5.8	699.2 ± 509.4
Qian et al. [25]	2013	16	59.5 ± 8.5	8.9 ± 2.9	STN-DBS	PSQI	24 months	12 ± 3	756.5 ± 255.2	12 ± 4	420.8 ± 300.1
Chen et al. [26]	2011	10	59 ± 10	9 ± 3	STN-DBS	PSQI	12 months	11 ± 3	711 ± 253	12 ± 4	361 ± 206
Iranzo et al. [27]	2002	11	63.6 ± 7.8	17.3 ± 9.1	STN-DBS	PSQI	6 months	14.8 ± 4.5	—	5.4 ± 4.6	—

IRLSSG criteria: International restless leg syndrome study group (IRLSSG) criteria; PSQI: the Pittsburgh sleep quality index (PSQI) questionnaire; and LE: levodopa equivalents.