Motor Improvement-Related Regional Cerebral Blood Flow Changes in Parkinson’s Disease in Response to Antiparkinsonian Drugs

Table 2

rCBF change in response to antiparkinsonian drugs and its correlation with motor improvement in the 30 PD patients.

VOI	Mean rCBF change index (% points)^†	r
Basal ganglia
Put	18.65 (SD 20.16)	0.28
Gpe	16.97 (SD 24.38)	0.16
Gpi	8.38 (SD 22.81)	0.04
SN	31.10 (SD 32.36)	0.37^†
Frontal cortex
ACC	−3.94 (SD 8.15)	0.45
DLPFC	2.16 (SD 3.15)	0.19
IFG	−4.65 (SD 11.54)	0.18
OFC	−6.30 (SD 10.11)	0.67
Thalamus
LG	17.22 (SD 35.42)	0.60^†
MG	22.62 (SD 40.03)	0.54^†
Pul	15.13 (SD 19.78)	0.18
VA	13.12 (SD 19.92)	0.08
VP	33.04 (SD 33.79)	0.01
Others
Ins	8.35 (SD 10.28)	0.16
PVC	0.79 (SD 1.99)	0.31
RN	29.21 (SD 40.14)	0.03
SSAC	9.73 (SD 11.81)	0.06

^†. Abbreviations for VOIs: ACC, anterior cingulate cortex; DLPFC, dorsolateral prefrontal cortex; GPe, external segment of globus pallidus; GPi, internal segment of globus pallidus; IFG, inferior frontal gyrus; Ins, insula; LG, lateral geniculate body; MG, medial geniculate body; OFC, orbitofrontal cortex; Pul, pulvinar; Put, putamen; PVC, primary visual cortex; RN, red nucleus; SN, substantia nigra; SSAC, somatosensory association cortex; VA, ventral anterior nucleus; VP, ventral posterior nucleus; PD, Parkinson’s disease; rCBF, regional cerebral blood flow; SD, standard deviation; VOI, volume of interest.