Automated Subfield Volumetric Analysis of Hippocampus in Patients with Drug-Naïve Nondementia Parkinson’s Disease
Table 2
The differences of the total and subfield hippocampal volumes between the groups determined by the diagnosis and by the hemisphere.
Subfield
Volume (mm3)
Diagnosis
Hemisphere
Diagnosis X hemisphere
HC
PD
Right
Left
Right
Left
F
F
F
CA1
316.88 ± 35.73
323.80 ± 44.40
316.59 ± 32.91
305.31 ± 33.55
0.680
0.417
0.374
0.546
1.732
0.199
CA2-3
905.50 ± 109.62
907.39 ± 153.15
922.81 ± 103.26
851.60 ± 87.20
0.308
0.584
1.946
0.174
7.586
0.010
CA4-DG
509.05 ± 53.49
514.72 ± 87.24
520.51 ± 58.62
480.69 ± 50.33
0.419
0.523
0.042
0.839
7.403
0.011
Presubiculum
429.68 ± 68.80
441.29 ± 80.29
402.54 ± 73.23
407.71 ± 70.40
1.900
0.179
0.143
0.708
0.122
0.730
Subiculum
594.36 ± 61.26
603.78 ± 68.22
579.25 ± 84.45
553.55 ± 75.52
2.398
0.133
1.274
0.269
2.998
0.095
Fimbria
46.48 ± 19.80
44.86 ± 21.47
38.21 ± 19.45
38.95 ± 21.18
0.880
0.356
0.001
0.971
0.107
0.747
Fissure
46.38 ± 22.34
39.14 ± 21.59
46.18 ± 15.15
32.61 ± 12.88
0.200
0.658
1.879
0.182
0.878
0.357
Total
2801.93 ± 280.20
2835.81 ± 388.63
2779.93 ± 323.33
2637.83 ± 277.87
1.379
0.250
0.084
0.774
5.197
0.031
Data are the mean ± standard deviation (mm3). Repeated-measures analysis of covariance (ANCOVA) controlling for age, sex, and total intracranial cavity volume was performed. “Diagnosis X hemisphere” means the interaction effect of diagnosis by hemisphere. FDR was applied in the comparisons of the total and subfield volumes (8 comparisons), . Regions that remained significant after FDR correction are marked with an asterisk. HC, healthy control group; PD, Parkinson’s disease, nondementia group; CA, cornu ammonis; DG, dentate gyrus; FDR, false discovery rate by Benjamini and Hochberg.
