AEs and ADRs in italics represent events reported in the ≥2000 mg dose group at twice the rate of that reported in the low-dose group. aExcluding those associated with the procedure/device. bRefers to the reemergence of Parkinson’s disease symptoms, often due to a problem with drug delivery. cADRs were AEs deemed by the investigator to have at least a reasonable possibility of a causal relationship to the treatment drug/device. ADR: adverse drug reaction; AE: adverse event.