|Author and year||Type of study||Method to assess studies’ quality||Finding||Limits|
|Saltychev et al. ||Systematic review and meta-analysis (12 RCTs)||Cochrane Collaboration’s domain-based evaluation framework||No evidence for the superiority of PRT compared to other physical training||Some relevant studies could remain undetected because of the uncertain definition of PRT|
|Tillman et al. ||Systematic review and meta-analysis (7 RCTs)||PEDro scale||On measures of gait and balance no evidence to support or refute PRT prescription; in conjunction with balance and task-specific functional training to improve these measures||The reduced sample size, which has been selected for the feasibility of conducting a one-to-one, 6-week exercise intervention.|
|Chung et al. ||Systematic review and meta-analysis (7 RCTs)||PEDro scale||PRT (2-3 times per week, 8–10 weeks) can enhance strength, balance and motor symptoms in early—moderate PD.||No blinding of subjects, intervention therapist and outcome assessors in the most of the RCTs.|
Outcome evaluation over short-term (8–14 weeks)
|Roeder et al. ||Systematic review and meta-analysis (9papers)||2 review authors using a customized form||Combining RT with other form of physical exercise could be most effective.|
Not enough data available to evidence-based guidelines for resistance training prescription
|Published reports did not provide sufficient details for judgment, then bias from selective reporting of results and from allocation concealment was difficult to determine; |
Since much was unknown about the quality of most included studies, it impacts on conclusions drawn from this review which are not definitive.
|Lima et al. ||Systematic review and meta—analysis (2 RCTs and 2 QRCTs.).||PEDro scale||Evidence to support PRT prescription in mild/moderate PD’s patients and to implemented it as an ordinary therapy in PD.||Only 4 studies included|
|Cruisckshank et al. ||Systematic review and meta-analysis (6RCTs + 3 non-RCTs about PD and 5RCTs + 2 non-RCTs about MS)||PEDro scale||Benefit in strength after RT, it has a positive effect on clinical disease progression and mobility.|
High-quality trials are needed.
|The heterogeneity of interventions and study outcomes in PD and MS trials|
|Uhrbrand et al. ||Systematic review and meta-analysis (9RCTs)||PEDro scale||Strong evidence in favor of muscle strength improving in PD.|
Inconsistent findings are about balance, walking performance and quality of life improving.
PRT may positively impact UPDRS-III and quality of life.
|Small sample size; short-term interventions (≤12 settimane)|
|Brienesse and Emerson ||Systematic review (3 RCTs and 2 non-RCTs.)||Modified version of PEDro scale||RCTs with a standardized and thorough reporting of intervention and functional outcomes are needed.||Methodological limitation in available papers (RCTs do not satisfy all of quality criteria); not well RT description/inadequate description of the training protocol.|