Research Article

Nicotine Has a Therapeutic Window of Effectiveness in a Drosophila melanogaster Model of Parkinson’s Disease

Figure 2

Nicotine treatment improves climbing deficits in park25 homozygotes. Nicotine (6 and 9 μg/mL) was given to homozygous park25 flies compared to control flies from day 0. Different climbing metrics are shown, see Methods for definitions. Data are presented as mean and SEM. Results from a post hoc Tukey HSD analysis are shown. Asterisks inside the bars compare between the two genotypes at individual nicotine levels. , , . The results of each data point are from at least four separate experiments with an n ≥ 56 flies.