Parkinson’s Disease

Animal Models of Parkinson's Disease


Publishing date
15 Mar 2011
Status
Published
Submission deadline
15 Sep 2010

Lead Editor

1Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan

2Ottawa Health Research Institute, Neuroscience Research Institute, 451 Smyth Road, Ottawa, ON, Canada K1H 8M5

3Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892-3707, USA

4Department of Bioinformatics and Molecular Genetics, and Center for Biological Systems Analysis, University of Freiburg, 79104 Freiburg, Germany


Animal Models of Parkinson's Disease

Description

Parkinson's disease (PD) is one of the most common movement disorders and is characterized by age-dependent dysfunction and degeneration of the midbrain dopaminergic neurons. Understanding of the pathogenic mechanism of PD has progressed with neurotoxin-induced PD model animals. Moreover, recent advances in human molecular genetics have led to the identification of several familial PD genes, including α-synuclein, parkin, PINK1, DJ-1, LRRK2, and ATP13A2. Analyses of model animals in which mutations of these PD genes are introduced promise to shed lights on the pathogenic mechanism underlying idiopathic PD as well as familial PD.

We particularly take an interest in manuscripts that report the molecular mechanisms of neurodegeneration, therapeutic challenges using model animals, development of new screening methods, and generation of new PD models. High-quality research articles related to the topic and reviews to summarize the most recent progresses are welcome. Moreover, papers dealing with new methods to detect degeneration of dopaminergic neurons as well as other cells would be of great interest. Main topics include, but are not limited to:

  • PD studies using vertebrate modelsn
  • PD studies using nonvertebrate models
  • PD studies using other organisms
  • Drug screening using PD model organisms
  • Development of therapeutic strategies using PD model organisms
  • Development of experimental techniques

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/pd/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 364328
  • - Editorial

Animal Models of Parkinson's Disease

Yuzuru Imai | Katerina Venderova | ... | Enrico Schmidt
  • Special Issue
  • - Volume 2011
  • - Article ID 987084
  • - Research Article

Effects of Human Alpha-Synuclein A53T-A30P Mutations on SVZ and Local Olfactory Bulb Cell Proliferation in a Transgenic Rat Model of Parkinson Disease

Faustine Lelan | Cécile Boyer | ... | Laurent Lescaudron
  • Special Issue
  • - Volume 2011
  • - Article ID 138471
  • - Research Article

MPTP Neurotoxicity and Testosterone Induce Dendritic Remodeling of Striatal Medium Spiny Neurons in the C57Bl/6 Mouse

Eleni Antzoulatos | Michael W. Jakowec | ... | Ruth I. Wood
  • Special Issue
  • - Volume 2011
  • - Article ID 307875
  • - Review Article

Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease

Kyota Fujita | Yusaku Nakabeppu | Mami Noda
  • Special Issue
  • - Volume 2011
  • - Article ID 942412
  • - Review Article

Models for LRRK2-Linked Parkinsonism

Tianxia Li | DeJun Yang | ... | Wanli W. Smith
  • Special Issue
  • - Volume 2011
  • - Article ID 414682
  • - Review Article

Optimizing a Rodent Model of Parkinson's Disease for Exploring the Effects and Mechanisms of Deep Brain Stimulation

Karl Nowak | Eilhard Mix | ... | Ulrike Gimsa
  • Special Issue
  • - Volume 2011
  • - Article ID 520640
  • - Review Article

Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies

Verónica Muñoz-Soriano | Nuria Paricio
  • Special Issue
  • - Volume 2011
  • - Article ID 124165
  • - Review Article

VMAT2-Deficient Mice Display Nigral and Extranigral Pathology and Motor and Nonmotor Symptoms of Parkinson's Disease

Tonya N. Taylor | W. Michael Caudle | Gary W. Miller
  • Special Issue
  • - Volume 2011
  • - Article ID 487450
  • - Review Article

The Endotoxin-Induced Neuroinflammation Model of Parkinson's Disease

Kemal Ugur Tufekci | Sermin Genc | Kursad Genc
  • Special Issue
  • - Volume 2011
  • - Article ID 951709
  • - Review Article

Toxin-Induced and Genetic Animal Models of Parkinson's Disease

Shin Hisahara | Shun Shimohama
Parkinson’s Disease
 Journal metrics
Acceptance rate39%
Submission to final decision99 days
Acceptance to publication31 days
CiteScore2.270
Impact Factor2.051
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