Parkinson’s Disease

Mitochondria and Parkinson's Disease


Publishing date
01 Apr 2011
Status
Published
Submission deadline
01 Oct 2010

Lead Editor

1Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02445, USA

2Division of Neuropathology, University of Pittsburgh School of Medicine, 200 Lothrop St., Rm. S417 BST, Pittsburgh, PA 15261, USA

3Department of Neurology, University of Kansas Medical Center, MS 2012, 3901 Rainbow Blvd, Kansas City, KS 66160-7401, USA


Mitochondria and Parkinson's Disease

Description

A large body of evidence implicates a central role for mitochondrial dysfunction in the pathogenesis of Parkinson's disease (PD), though the precise causes of mitochondrial dysfunction in PD remain to be determined. Mitochondrial complex I activity is impaired in the substantia nigra at early stages in PD. This complex I dysfunction appears not to be simply a consequence of neurodegeneration as toxins that inhibit mitochondrial complex I can reproduce many of the key pathological features of PD in animal models. Several genetic causes of PD have been linked directly or indirectly to mitochondrial function, and thus a convergence of data highlight the role of mitochondrial dysfunction in PD.

We are particularly interested in reviews that critically evaluate the scientific literature in cellular and animal models of Parkinson's disease. Manuscripts that focus on data from human studies also are welcome. Papers focusing on oxidative stress will be considered if they address the role of mitochondria as the source or target of oxidative stress. We encourage both reviews as well as manuscripts that present original data. Main topics include, but are not limited to:

  • Mitochondrial toxins
  • Mitophagy
  • Mitochondrial Fusion/Fission and Transport
  • Mitochondria and calcium homeostasis
  • Imaging (e.g., MRS)
  • Oxidative stress
  • Link between genetic causes of PD and mitochondrial dysfunction (alpha-synuclein, parkin, DJ-1, PINK1, etc.)
  • Role of genetic variations in components of the respiratory enzyme chain in Parkinson's disease
  • Inherited mtDNA mutations
  • Somatic mtDNA mutations
  • Mitochondria as targets for neuroprotection (uncouplers, PGC-1alpha, CoQ10, etc.)

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/pd/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 261791
  • - Editorial

Mitochondria and Parkinson's Disease

David K. Simon | Charleen T. Chu | Russell H. Swerdlow
  • Special Issue
  • - Volume 2011
  • - Article ID 159160
  • - Review Article

Mitochondrial Contribution to Parkinson's Disease Pathogenesis

Anthony H. V. Schapira | Matthew Gegg
  • Special Issue
  • - Volume 2011
  • - Article ID 659694
  • - Review Article

Do Somatic Mitochondrial DNA Mutations Contribute to Parkinson's Disease?

Joanne Clark | Ying Dai | David K. Simon
  • Special Issue
  • - Volume 2011
  • - Article ID 789431
  • - Review Article

Diversity in the Regulation of Autophagy and Mitophagy: Lessons from Parkinson's Disease

Charleen T. Chu
  • Special Issue
  • - Volume 2011
  • - Article ID 153979
  • - Research Article

PINK1-Interacting Proteins: Proteomic Analysis of Overexpressed PINK1

Aleksandar Rakovic | Anne Grünewald | ... | Christine Klein
  • Special Issue
  • - Volume 2011
  • - Article ID 716871
  • - Review Article

Mitochondrial Dysfunction in Parkinson's Disease

P. C. Keane | M. Kurzawa | ... | C. M. Morris
  • Special Issue
  • - Volume 2011
  • - Article ID 314082
  • - Review Article

The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease

Kemal Ugur Tufekci | Ezgi Civi Bayin | ... | Kursad Genc
  • Special Issue
  • - Volume 2011
  • - Article ID 767230
  • - Review Article

Mitochondrial Fusion/Fission, Transport and Autophagy in Parkinson's Disease: When Mitochondria Get Nasty

Daniela M. Arduíno | A. Raquel Esteves | Sandra M. Cardoso
  • Special Issue
  • - Volume 2011
  • - Article ID 693761
  • - Review Article

Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD

A. R. Esteves | D. M. Arduíno | ... | S. M. Cardoso
  • Special Issue
  • - Volume 2011
  • - Article ID 617472
  • - Review Article

Mitochondrial Dysfunction in Parkinson's Disease: Pathogenesis and Neuroprotection

Ross B. Mounsey | Peter Teismann
Parkinson’s Disease
 Journal metrics
Acceptance rate51%
Submission to final decision75 days
Acceptance to publication35 days
CiteScore3.500
Journal Citation Indicator0.560
Impact Factor2.704
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