Table 3: Female UCN1KO mice do not acclimatize to cold environment. Statistical comparison of average rectal temperatures, taken every 10 min during 2 h (10 to 13 measurements for each mouse, 3 to 8 animals in each group) in mice exposed 2 times to 4°C. The second time was performed 3 days after the first attempt. Statistical analysis was made using ANOVA followed by Student’s -test.

GenotypeSexAttempt numberRectal temperature (°C) means ± SD ( ) values(a)

WTMales1st36.9 ± 0.87<0.001
2nd37.4 ± 0.67
Females1st37.3 ± 0.47<0.001
2nd38.0 ± 0.43

UCN1KOMales1st37.3 ± 0.76<0.05
2nd37.8 ± 0.63
Females1st37.8 ± 0.58NS
2nd37.6 ± 0.56