Table of Contents
Physiology Journal
Volume 2014 (2014), Article ID 256236, 5 pages
http://dx.doi.org/10.1155/2014/256236
Research Article

Dietary Consumption of Virgin Coconut Oil Ameliorates Lipid Profiles in Diabetic Rats

1Department of Human Physiology, Cross River University of Technology, Okuku Campus, Yala, Cross River State, Nigeria
2Department of Physiology, Bowen University, Iwo, Osun State, Nigeria

Received 24 August 2014; Revised 12 September 2014; Accepted 14 September 2014; Published 29 September 2014

Academic Editor: Gary Lopaschuk

Copyright © 2014 A. M. Akinnuga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Virgin coconut oil (VCO) is a saturated fat with promising antidiabetic properties but its ameliorative effect on lipid profiles in diabetics is rarely reported. Therefore, in this study, a total of fifteen (15) male rats weighing 200–250 g were divided into 3 experimental groups (). Group I (control) and Group II (diabetic control group) were fed a normal rat chow while Group III (diabetic test group) was fed a 10% VCO diet for 3 weeks. Group II and Group III were made diabetic by intraperitoneal injection of 150 mg/kg of alloxan. After 72 hours of injection, blood glucose was tested to confirm diabetes mellitus. After 3 weeks, the animals were sacrificed to collect blood samples for lipid profile analysis. The results showed a significant increase in concentrations of triglyceride, total cholesterol, low density lipoprotein, and very low density lipoprotein and decrease in concentration of high density lipoprotein in Group II when compared to Group I. Also, the concentrations of triglyceride, total cholesterol, low density lipoprotein, and very low density lipoprotein except high density lipoprotein significantly reduced in Group III when compared to Group II (, 0.001). VCO consumption can be claimed to ameliorate lipid levels in diabetes mellitus.