A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography

Table 2

Characteristics of patients in SP-D and SP-D&KL-6 group.

	SP-D group	SP-D&KL-6 group	P values
Age yrs	71 ± 2.2 (𝑛=6)	66 ± 2.1 (𝑛=11)	.19
Pack-yrs	28.6 ± 11.5 (𝑛=4)	31.0 ± 12.2 (𝑛=8)	.72
VC %pred	102.4 ± 7.3 (𝑛=5)	82.5 ± 4.5 (𝑛=9)	.045*
FEV1.0/FVC (%)	82.9 ± 5.1 (𝑛=5)	87.3 ± 2.1 (𝑛=9)	.69
DLCO  %pred	71.6 ± 16.5 (𝑛=3)	61.6 ± 7.8 (𝑛=9)	.051
RV/TLC (%)	34.9 ± 4.1 (𝑛=3)	32.9 ± 1.7 (𝑛=9)	.40
SP-D ng/ml	336 ± 40.3 (𝑛=6)	375 ± 30.8 (𝑛=11)	.48
KL-6/MUC1 U/ml	393 ± 20.5 (𝑛=6)	1439 ± 169 (𝑛=11)	<.001*
HRCT scan fibrotic area (%)
Aortic arch	0.7 ± 0.2 (𝑛=6)	14.9 ± 4.7 (𝑛=11)	<.001*
Carina	1.1 ± 0.5 (𝑛=6)	15.8 ± 5.6 (𝑛=11)	<.001*
Top of diaphragm	5.4 ± 2.4 (𝑛=6)	33.4 ± 7.6 (𝑛=11)	<.001*

Data are presented as mean ± S.E. SP-D group: SP-D > 220 ng/ml and KL-6 < 500 U/ml; SP-D&KL-6 group: SP-D > 220 ng/ml and KL-6 > 1000 U/ml. *: 𝑃<.05.