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Pulmonary Medicine
Volume 2011 (2011), Article ID 918036, 10 pages
http://dx.doi.org/10.1155/2011/918036
Research Article

Perfluorochemical Liquid-Adenovirus Suspensions Enhance Gene Delivery to the Distal Lung

1The Cardiopulmonary Research Institute and Departments of Medicine and Pediatrics, SUNY Stony Brook School of Medicine, Winthrop University Hospital, Mineola, NY 11507, USA
2Department of Pathology, Thomas Jefferson University Medical Center, Philadelphia, PA 19107, USA
3Departments of Physiology and Pediatrics, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA
4Nemours Research Lung Center, Alfred I. DuPont Hospital for Children, Wilmington, DE 19803, USA
5Department of Pediatrics, The Floating Hospital for Children at Tufts Medical Center, Boston, MA 02111, USA
6Center for Inflammation, Translational, and Clinical Lung Research (CILR) and Temple Lung Center, Temple University School of Medicine, Philadelphia, PA 19140, USA

Received 7 March 2011; Accepted 24 May 2011

Academic Editor: Edwin Chilvers

Copyright © 2011 Jeffrey A. Kazzaz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Kolb, G. Martin, M. Medina, K. Ask, and J. Gauldie, “Gene therapy for pulmonary diseases,” Chest, vol. 130, no. 3, pp. 879–884, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. R. J. Pickles, “Physical and biological barriers to viral vector-mediated delivery of genes to the airway epithelium,” Proceedings of the American Thoracic Society, vol. 1, no. 4, pp. 302–308, 2004. View at Google Scholar · View at Scopus
  3. D. J. Weiss, T. Beckett, L. Bonneau, J. Young, J. K. Kolls, and G. Wang, “Transient increase in lung epithelial tight junction permeability: an additional mechanism for enhancement of lung transgene expression by perfluorochemical liquids,” Molecular Therapy, vol. 8, no. 6, pp. 927–935, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. Q. Chu, J. A. St. George, M. Lukason, S. H. Cheng, R. K. Scheule, and S. J. Eastman, “EGTA enhancement of adenovirus-mediated gene transfer to mouse tracheal epithelium in vivo,” Human Gene Therapy, vol. 12, no. 5, pp. 455–467, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. G. Wang, J. Zabner, C. Deering et al., “Increasing epithelial junction permeability enhances gene transfer to airway epithelia in vivo,” American Journal of Respiratory Cell and Molecular Biology, vol. 22, no. 2, pp. 129–138, 2000. View at Google Scholar · View at Scopus
  6. J. T. Li, L. A. Bonneau, J. J. Zimmerman, and D. J. Weiss, “Perfluorochemical (PFC) liquid enhances recombinant adenovirus vector-mediated viral interleukin-10 (AdvIL-10) expression in rodent lung,” Journal of Inflammation, vol. 4, article 9, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. D. J. Weiss, T. P. Strandjord, D. Liggitt, and J. G. Clark, “Perflubron enhances adenovirus-mediated gene expression in lungs of transgenic mice with chronic alveolar filling,” Human Gene Therapy, vol. 10, no. 14, pp. 2287–2293, 1999. View at Publisher · View at Google Scholar · View at Scopus
  8. D. J. Weiss, T. P. Strandjord, J. C. Jackson, J. G. Clark, and D. Liggitt, “Perfluorochemical liquid-enhanced adenoviral vector distribution and expression in lungs of spontaneously breathing rodents,” Experimental Lung Research, vol. 25, no. 4, pp. 317–333, 1999. View at Publisher · View at Google Scholar · View at Scopus
  9. D. J. Weiss, L. Bonneau, and D. Liggitt, “Use of perfluorochemical liquid allows earlier detection of gene expression and use of less vector in normal lung and enhances gene expression in acutely injured lung,” Molecular Therapy, vol. 3, no. 5, pp. 734–745, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. D. J. Weiss, G. B. Baskin, M. K. Shean, J. L. Blanchard, and J. K. Kolls, “Use of perflubron to enhance lung gene expression: safety and initial efficacy studies in non-human primates,” Molecular Therapy, vol. 5, no. 1, pp. 8–15, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. D. A. Lisby, P. L. Ballard, W. W. Fox, M. R. Wolfson, T. H. Shaffer, and L. W. Gonzales, “Enhanced distribution of adenovirus-mediated gene transfer to lung parenchyma by perfluorochemical liquid,” Human Gene Therapy, vol. 8, no. 8, pp. 919–928, 1997. View at Google Scholar · View at Scopus
  12. C. A. Cox, R. L. Stavis, M. R. Wolfson, and T. H. Shaffer, “Long-term tidal liquid ventilation in premature lambs: physiologic, biochemical and histological correlates,” Biology of the Neonate, vol. 84, no. 3, pp. 232–242, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. M. J. Jeng, S. S. Yang, M. R. Wolfson, and T. H. Shaffer, “Perfluorochemical (PFC) combinations for acute lung injury: an in vitro and in vivo study in juvenile rabbits,” Pediatric Research, vol. 53, no. 1, pp. 81–88, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. T. F. Miller, B. Milestone, R. Stern, T. H. Shaffer, and M. R. Wolfson, “Effects of perfluorochemical distribution and elimination dynamics on cardiopulmonary function,” Journal of Applied Physiology, vol. 90, no. 3, pp. 839–849, 2001. View at Google Scholar · View at Scopus
  15. B. N. Shashikant, T. L. Miller, M. J. Jeng, J. Davis, T. H. Shaffer, and M. R. Wolfson, “Differential impact of perfluorochemical physical properties on the physiologic, histologic, and inflammatory profile in acute lung injury,” Critical Care Medicine, vol. 33, no. 5, pp. 1096–1103, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. R. L. Stavis, M. R. Wolfson, C. A. Cox, N. Kechner, and T. H. Shaffer, “Physiologic, biochemical, and histologic correlates associated with tidal liquid ventilation,” Pediatric Research, vol. 43, no. 1, pp. 132–138, 1998. View at Google Scholar · View at Scopus
  17. M. R. Wolfson, N. E. Kechner, R. F. Roache et al., “Perfluorochemical rescue after surfactant treatment: effect of perflubron dose and ventilatory frequency,” Journal of Applied Physiology, vol. 84, no. 2, pp. 624–640, 1998. View at Google Scholar · View at Scopus
  18. M. R. Wolfson, J. S. Greenspan, K. S. Deoras, S. D. Rubenstein, and T. H. Shaffer, “Comparison of gas and liquid ventilation: clinical, physiological, and histological correlates,” Journal of Applied Physiology, vol. 72, no. 3, pp. 1024–1031, 1992. View at Google Scholar · View at Scopus
  19. A. T. Rotta, B. Gunnarsson, L. J. Hernan, B. P. Fuhrman, and D. M. Steinhorn, “Partial liquid ventilation with perflubron attenuates in vivo oxidative damage to proteins and lipids,” Critical Care Medicine, vol. 28, no. 1, pp. 202–208, 2000. View at Google Scholar · View at Scopus
  20. D. M. Steinhorn, M. C. Papo, A. T. Rotta, A. Aljada, B. P. Fuhrman, and P. Dandona, “Liquid ventilation attenuates pulmonary oxidative damage,” Journal of Critical Care, vol. 14, no. 1, pp. 20–28, 1999. View at Publisher · View at Google Scholar · View at Scopus
  21. M. A. Croce, T. C. Fabian, J. H. Patton, S. M. Melton, M. Moore, and L. L. Trenthem, “Partial liquid ventilation decreases the inflammatory response in the alveolar environment of trauma patients,” Journal of Trauma, vol. 45, no. 2, pp. 273–282, 1998. View at Google Scholar · View at Scopus
  22. M. R. Wolfson and T. H. Shaffer, “Liquid ventilation: an adjunct for respiratory management,” Paediatric Anaesthesia, vol. 14, no. 1, pp. 15–23, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. M. R. Wolfson and T. H. Shaffer, “Pulmonary applications of perfluorochemical liquids: ventilation and beyond,” Paediatric Respiratory Reviews, vol. 6, no. 2, pp. 117–127, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Varani, R. B. Hirschl, M. Dame, and K. Johnson, “Perfluorocarbon protects lung epithelial cells from neutrophil-mediated injury in an in vitro model of liquid ventilation therapy,” Shock, vol. 6, no. 5, pp. 339–344, 1996. View at Google Scholar · View at Scopus
  25. V. V. Obraztsov, G. G. Neslund, E. S. Kornbrust, S. F. Flaim, and C. M. Woods, “In vitro cellular effects of perfluorochemicals correlate with their lipid solubility,” American Journal of Physiology, vol. 278, no. 5, pp. L1018–L1024, 2000. View at Google Scholar · View at Scopus
  26. C. M. Woods, G. Neslund, E. Kornbrust, and S. F. Flaim, “Perflubron attenuates neutrophil adhesion to activated endothelial cells in vitro,” American Journal of Physiology, vol. 278, no. 5, pp. L1008–L1017, 2000. View at Google Scholar · View at Scopus
  27. B. Nakstad, M. R. Wolfson, T. H. Shaffer et al., “Perfluorochemical liquids modulate cell-mediated inflammatory responses,” Critical Care Medicine, vol. 29, no. 9, pp. 1731–1737, 2001. View at Google Scholar · View at Scopus
  28. B. Venegas, M. R. Wolfson, P. H. Cooke, and P. L. G. Chong, “High vapor pressure perfluorocarbons cause vesicle fusion and changes in membrane packing,” Biophysical Journal, vol. 95, no. 10, pp. 4737–4747, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. J. L. Gabriel, T. F. Miller, M. R. Wolfson, and T. H. Shaffer, “Quantitative structure-activity relationships of perfluorinated hetero- hydrocarbons as potential respiratory media: application to oxygen solubility, partition coefficient, viscosity, vapor pressure, and density,” ASAIO Journal, vol. 42, no. 6, pp. 968–973, 1996. View at Google Scholar · View at Scopus
  30. T. H. Shaffer, R. Foust, M. R. Wolfson, and T. F. Miller, “Analysis of perfluorochemical elimination from the respiratory system,” Journal of Applied Physiology, vol. 83, no. 3, pp. 1033–1040, 1997. View at Google Scholar · View at Scopus
  31. A. Wemhöner, I. Hackspiel, N. Hobi, A. Ravasio, T. Haller, and M. Rüdiger, “Effects of perfluorocarbons on surfactant exocytosis and membrane properties in isolated alveolar type II cells,” Respiratory Research, vol. 11, article 52, 2010. View at Google Scholar · View at Scopus
  32. B. L. Davidson, E. D. Allen, K. F. Kozarsky, J. M. Wilson, and B. J. Roessler, “A model system for in vivo gene transfer into the central nervous system using an adenoviral vector,” Nature Genetics, vol. 3, no. 3, pp. 219–223, 1993. View at Publisher · View at Google Scholar · View at Scopus
  33. C. A. Cox, A. B. Cullen, M. R. Wolfson, and T. H. Shaffer, “Intratracheal administration of perfluorochemical-gentamicin suspension: a comparison to intravenous administration in normal and injured lungs,” Pediatric Pulmonology, vol. 32, no. 2, pp. 142–151, 2001. View at Publisher · View at Google Scholar · View at Scopus
  34. A. B. Cullen, C. A. Cox, S. J. Hipp, M. R. Wolfson, and T. H. Shaffer, “Intra-tracheal delivery strategy of gentamicin with partial liquid ventilation,” Respiratory Medicine, vol. 93, no. 11, pp. 770–778, 1999. View at Google Scholar · View at Scopus
  35. K. Sarafidis, D. J. Malone, G. Zhu et al., “Perfluorochemical augmented rhSOD delivery attenuates inflammation in the immature lung,” Journal of Neonatal-Perinatal Medicine, vol. 1, pp. 159–168, 2008. View at Google Scholar
  36. M. Rüdiger, S. Wendt, L. Köthe, W. Burkhardt, R. R. Wauer, and M. Ochs, “Alterations of alveolar type II cells and intraalveolar surfactant after bronchoalveolar lavage and perfluorocarbon ventilation. An electron microscopical and stereological study in the rat lung,” Respiratory Research, vol. 8, article 40, 2007. View at Publisher · View at Google Scholar
  37. P. L. Sinn, A. J. Shah, M. D. Donovan, and P. B. McCray, “Viscoelastic gel formulations enhance airway epithelial gene transfer with viral vectors,” American Journal of Respiratory Cell and Molecular Biology, vol. 32, no. 5, pp. 404–410, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. M. S. Strayer, S. H. Guttentag, and P. L. Ballard, “Targeting type II and Clara cells for adenovirus-mediated gene transfer using the surfactant protein B promoter,” American Journal of Respiratory Cell and Molecular Biology, vol. 18, no. 1, pp. 1–11, 1998. View at Google Scholar · View at Scopus
  39. L. Brunelli, E. Hamilton, J. M. Davis et al., “Perfluorochemical liquids enhance delivery of superoxide dismutase to the lungs of juvenile rabbits,” Pediatric Research, vol. 60, no. 1, pp. 65–70, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. H. Cao, D. R. Koehler, and J. Hu, “Adenoviral vectors for gene replacement therapy,” Viral Immunology, vol. 17, no. 3, pp. 327–333, 2004. View at Publisher · View at Google Scholar · View at Scopus
  41. S. J. Hedley, A. Auf der Maur, S. Hohn et al., “An adenovirus vector with a chimeric fiber incorporating stabilized single chain antibody achieves targeted gene delivery,” Gene Therapy, vol. 13, no. 1, pp. 88–94, 2006. View at Publisher · View at Google Scholar · View at Scopus
  42. N. Koizumi, H. Mizuguchi, M. Kondoh, M. Fujii, T. Hayakawa, and Y. Watanabe, “Efficient gene transfer into human trophoblast cells with adenovirus vector containing chimeric type 5 and 35 fiber protein,” Biological and Pharmaceutical Bulletin, vol. 27, no. 12, pp. 2046–2048, 2004. View at Publisher · View at Google Scholar · View at Scopus
  43. D. M. Steinhorn, M. C. Papo, A. Aljada, K. Thusu, B. P. Fuhrman, and P. Dandonna, “Partial liquid ventilation (PLV) with perflubron decreases oxidative damage to the lung during experimental injury,” Critical Care Medicine, vol. 24, article A148, 1996. View at Google Scholar