Ancillary Testing in Lung Cancer Diagnosis

Table 3

Clinically relevant molecular and clinicopathologic features of NSCLC.

	EGFR mutation	K-ras mutation	EML4-ALK mutation
Histologic subtype	Adenocarcinoma	NSCLC (Adeno > squamous)	Adenocarcinoma, signet ring morphology
Clinical features	Asian, female, light/never smokers	Past or present smokers	Light/never smokers, possible young age and male
Significance	Sensitive to EGFR TKI therapy	Relative resistance to EGFR TKI therapy, possible poor prognostic marker	Use of ALK inhibitors (currently under study)