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Pulmonary Medicine
Volume 2012, Article ID 273591, 10 pages
Review Article

Etiopathogenetic Mechanisms of Pulmonary Hypertension in Sleep-Related Breathing Disorders

1Department of Internal Medicine, Mercy Fitzgerald Hospital, Darby, PA 19018, USA
2Sleep Medicine Services, Bryn Mawr Hospital, PA 19010, USA

Received 27 February 2012; Accepted 4 June 2012

Academic Editor: Gulfer Okumus

Copyright © 2012 Ayodeji Adegunsoye and Siva Ramachandran. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Obstructive sleep apnea syndrome is a common disorder with significant health consequences and is on the rise in consonance with the obesity pandemic. In view of the association between sleep-disordered breathing and pulmonary hypertension as depicted by multiple studies, current clinical practice guidelines categorize obstructive sleep apnea as a risk factor for pulmonary hypertension and recommend an assessment for sleep disordered breathing in evaluating patients with pulmonary hypertension. The dysregulatory mechanisms associated with hypoxemic episodes observed in sleep related breathing disorders contribute to the onset of pulmonary hypertension and identification of these potentially treatable factors might help in the reduction of overall cardiovascular mortality.