Oligometastatic Disease at Presentation or Recurrence for Nonsmall Cell Lung Cancer

Table 2

Selected studies of local treatment in oligometastatic NSCLC with mixed metastatic sites.

Study	Year	N	Criteria	Treatment	Findings
Hanagiri et al. [21] (retrospective)	2011	36	Up to 5 metastastic sites, stage IV disease	Surgery or radiation	5-year OS with distant metastasis 30.1%, pleural dissemination 25.1%
Guerra et al. [22] (retrospective)	2012	78	Up to 5 synchronous metastatic sites, Definitive chemoRT (44 also underwent treatment to OM sites)	Surgery or radiation to OM sites	High radiation dose, performance status, lower intrathoracic tumor volume correlated with improved OS
Downey et al. [23] (prospective)	2002	23	Solitary synchronous lesions	MVP × 3, then surgery on all sites, then VP × 2	MVP poorly tolerated, 2/23 patients disease free at 5 years