Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain)

Table 2

Frequency of MBL2 haplotypes in controls and PTB patients from Cantabria compared with other previously reported populations.

Haplotype	Population
	Controls	PTB	CAN	ESK	DAN	JAP	KEN	MOZ	CHIR	MAP	WAR
	(𝑛=441)	(𝑛=107)	(𝑛=344)	(𝑛=72)	(𝑛=250)	(𝑛=218)	(𝑛=61)	(𝑛=154)	(𝑛=43)	(𝑛=25)	(𝑛=190)
HYPA	0.28	0.30	0.24	0.81	0.31	0.44	0.08	0.06	0.54	0.38	0.75
LYQA	0.23	0.23	0.22	0	0.19	0.16	0.25	0.27	0.01	0	0.01
LYPA	0.07	0.08	0.08	0.04	0.04	0.07	0.13	0.30	0.02	0.08	0.23
LXPA	0.21	0.23	0.19	0.03	0.26	0.11	0.24	0.13	0.01	0.04	0.01
LYPB	0.14	0.13	0.17	0.12	0.11	0.22	0.02	0	0.42	0.46	0
LYQC	0.01	0.01	0.03	0	0.03	0	0.24	0.24	0	0.04	0
HYPD	0.07	0.02 ^a	0.07	0	0.06	0	0.04	0	0	0	0.003
H^b	0.81	0.82	0.82	0.33	0.79	0.72	0.81	0.76	0.54	0.66	0.39

Controls, healthy population from Cantabria, PTB, patients with pulmonary tuberculosis from Cantabria, CAN, and Gran Canaria p; ESK, Eskimo; DAN, Danish; JAP, Japanese; KEN, Kenya; MOZ, Mozambique; CHIR, Chiriguano (South America); MAP, Mapuche (South America); WAR, Warlpiri (Australia) populations.
^aP value 0.014 (OR 0.33 and 95% CI 0.13–0.84): frequency of HYPD haplotype in PTB patients versus control subjects from Cantabria.
^bAverage heterozygosity of the seven alleles when they were considered together.