The Diagnostic Value of the Interstitial Biomarkers KL-6 and SP-D for the Degree of Fibrosis in Combined Pulmonary Fibrosis and Emphysema

Table 3

Age and smoking history, KL-6, SP-D, pulmonary function tests, CPI in CPFE without lung cancer (CPFE without CA), and CPFE with lung cancer (CPFE with CA) at diagnosis.

	CPFE without CA	CPFE with CA	P value
Age, years	66.6±8.4	67.3±9.3	0.82
Smoking history, pack years	50.9±21.4	73.6±46.7	0.08
KL-6 (U/mL)	1443±1234	629±384	0.002
SP-D (ng/mL)	199.9±108.7	160.1±98.1	0.23
%VC	94.5±14.7	95.3±19.4	0.87
%FVC	93.9±15.1	94.8±19.9	0.88
%FEV1.0	97.0±13.8	95.1±25.1	0.81
FEV1.0/FVC (%)	79.6±9.2	75.4±12.1	0.22
%FRC	77.8±20.1	100±32.1	0.02
%RV/TLC	83.8±18.9	108.5±25.3	0.003
%DLco	67.4±14.9	66.4±20.1	0.86
CPI	30.2±12.5	30.5±15.4	0.95