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Pulmonary Medicine
Volume 2012, Article ID 568690, 9 pages
http://dx.doi.org/10.1155/2012/568690
Review Article

Positive Pressure for Obesity Hypoventilation Syndrome

1Section of Pulmonary, Critical Care, and Sleep Medicine, Bridgeport Hospital, Bridgeport, CT 06610, USA
2Hospital of Central Connecticut, 100 Grand Street, New Britain, CT 06050, USA

Received 9 April 2012; Revised 10 August 2012; Accepted 24 August 2012

Academic Editor: Kazuo Chin

Copyright © 2012 Arijit Chanda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. S. Burwell, E. D. Robin, R. D. Whaley, and A. G. Bickelmann, “Extreme obesity associated with alveolar hypoventilation—a Pickwickian syndrome,” The American journal of medicine, vol. 21, no. 5, pp. 811–818, 1956. View at Google Scholar · View at Scopus
  2. J. D. Hackney, M. G. Crane, C. C. Collier, S. Rokaw, and D. E. Griggs, “Syndrome of extreme obesity and hypoventilation: studies of etiology,” Annals of internal medicine, vol. 51, pp. 541–552, 1959. View at Google Scholar · View at Scopus
  3. B. Mokhlesi, “Obesity hypoventilation syndrome: a state-of-the-art review,” Respiratory Care, vol. 55, no. 10, pp. 1347–1362, 2010. View at Google Scholar · View at Scopus
  4. A. J. Piper and R. R. Grunstein, “Obesity hypoventilation syndrome: Mechanisms and management,” American Journal of Respiratory and Critical Care Medicine, vol. 183, no. 3, pp. 292–298, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. K. M. Flegal, M. D. Carroll, C. L. Ogden, and L. R. Curtin, “Prevalence and trends in obesity among US adults, 1999–2008,” Journal of the American Medical Association, vol. 303, no. 3, pp. 235–241, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Sturm, “Increases in clinically severe obesity in the United States, 1986–2000,” Archives of Internal Medicine, vol. 163, no. 18, pp. 2146–2148, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. Word Health Organization, “Controlling the global obesity epidemic,” http://www.who.int/nutrition/topics/obesity/en/, 2012.
  8. S. Nowbar, K. M. Burkart, R. Gonzales et al., “Obesity-associated hypoventilation in hospitalized patients: prevalence, effects, and outcome,” American Journal of Medicine, vol. 116, no. 1, pp. 1–7, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. P. Pelosi, M. Croci, I. Ravagnan et al., “Respiratory system mechanics in sedated, paralyzed, morbidly obese patients,” Journal of Applied Physiology, vol. 82, no. 3, pp. 811–818, 1997. View at Google Scholar · View at Scopus
  10. D. D. Sin, R. L. Jones, and S. F. Paul Man, “Obesity is a risk factor for dyspnea but not for airflow obstruction,” Archives of Internal Medicine, vol. 162, no. 13, pp. 1477–1481, 2002. View at Google Scholar · View at Scopus
  11. A. H. Gifford, J. C. Leiter, and H. L. Manning, “Respiratory function in an obese patient with sleep-disordered breathing,” Chest, vol. 138, no. 3, pp. 704–715, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Steier, C. J. Jolley, J. Seymour, M. Roughton, M. I. Polkey, and J. Moxham, “Neural respiratory drive in obesity,” Thorax, vol. 64, no. 8, pp. 719–725, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Gilbert, J. H. Sipple, and J. H. Auchincloss Jr., “Respiratory control and work of breathing in obese subjects,” Journal of applied physiology, vol. 16, pp. 21–26, 1961. View at Google Scholar · View at Scopus
  14. J. P. Kress, A. S. Pohlman, J. Alverdy, and J. B. Hall, “The impact of morbid obesity on oxygen cost of breathing (VO(2RESP)) at rest,” American Journal of Respiratory and Critical Care Medicine, vol. 160, no. 3, pp. 883–886, 1999. View at Google Scholar · View at Scopus
  15. N. K. Burki and R. W. Baker, “Ventilatory regulation in eucapnic morbid obesity,” American Review of Respiratory Disease, vol. 129, no. 4, pp. 538–543, 1984. View at Google Scholar · View at Scopus
  16. C. W. Zwillich, F. D. Sutton, and D. J. Pierson, “Decreased hypoxic ventilatory drive in the obesity hypoventilation syndrome,” American Journal of Medicine, vol. 59, no. 3, pp. 343–348, 1975. View at Google Scholar · View at Scopus
  17. C. P. O'Donnell, C. D. Schaub, A. S. Haines et al., “Leptin prevents respiratory depression in obesity,” American Journal of Respiratory and Critical Care Medicine, vol. 159, no. 5, part 1, pp. 1477–1484, 1999. View at Google Scholar · View at Scopus
  18. S. Redolfi, L. Corda, G. La Piana, S. Spandrio, P. Prometti, and C. Tantucci, “Long-term non-invasive ventilation increases chemosensitivity and leptin in obesity-hypoventilation syndrome,” Respiratory Medicine, vol. 101, no. 6, pp. 1191–1195, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. P. R. Phipps, E. Starritt, I. Caterson, and R. R. Grunstein, “Association of serum leptin with hypoventilation in human obesity,” Thorax, vol. 57, no. 1, pp. 75–76, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Campo, G. Frühbeck, J. J. Zulueta et al., “Hyperleptinaemia, respiratory drive and hypercapnic response in obese patients,” European Respiratory Journal, vol. 30, no. 2, pp. 223–231, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Kessler, A. Chaouat, P. Schinkewitch et al., “The obesity-hypoventilation syndrome revisited: a prospective study of 34 consecutive cases,” Chest, vol. 120, no. 2, pp. 369–376, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. K. I. Berger, I. Ayappa, I. B. Sorkin, R. G. Norman, D. M. Rapoport, and R. M. Goldring, “CO2 homeostasis during periodic breathing in obstructive sleep apnea,” Journal of Applied Physiology, vol. 88, no. 1, pp. 257–264, 2000. View at Google Scholar · View at Scopus
  23. K. I. Berger, I. Ayappa, B. Chatr-Amontri et al., “Obesity hypoventilation syndrome as a spectrum of respiratory disturbances during sleep,” Chest, vol. 120, no. 4, pp. 1231–1238, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. A. J. Piper, “Obesity hypoventilation syndrome—the big and the breathless,” Sleep Medicine Reviews, vol. 15, no. 2, pp. 79–89, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. B. Mokhlesi, M. H. Kryger, and R. R. Grunstein, “Assessment and management of patients with obesity hypoventilation syndrome,” Proceedings of the American Thoracic Society, vol. 5, no. 2, pp. 218–225, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. W. Hida, S. Okabe, K. Tatsumi et al., “Nasal continuous positive airway pressure improves quality of life in obesity hypoventilation syndrome,” Sleep and Breathing, vol. 7, no. 1, pp. 3–12, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. G. Berg, K. Delaive, J. Manfreda, R. Walld, and M. H. Kryger, “The use of health-care resources in obesity-hypoventilation syndrome,” Chest, vol. 120, no. 2, pp. 377–383, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Wijesinghe, M. Williams, K. Perrin, M. Weatherall, and R. Beasley, “The effect of supplemental oxygen on hypercapnia in subjects with obesity-associated hypoventilation: a randomized, crossover, clinical study,” Chest, vol. 139, no. 5, pp. 1018–1024, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. C. A. Manthous, “Oxymoronic Medicine,” http://gme.bridgeporthospital.com/Portals/7/Images/05/Hospitalistpocketversion08_2 011doc.pdf.
  30. L. A. P. De Llano, R. Golpe, M. O. Piquer et al., “Short-term and long-term effects of nasal intermittent positive pressure ventilation in patients with obesity-hypoventilation syndrome,” Chest, vol. 128, no. 2, pp. 587–594, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Budweiser, S. G. Riedl, R. A. Jörres, F. Heinemann, and M. Pfeifer, “Mortality and prognostic factors in patients with obesity-hypoventilation syndrome undergoing noninvasive ventilation,” Journal of Internal Medicine, vol. 261, no. 4, pp. 375–383, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. R. C. Basner, “Continuous positive airway pressure for obstructive sleep apnea,” The New England Journal of Medicine, vol. 356, no. 17, pp. 1751–1758, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. W. Pankow, N. Hijjeh, F. Schüttler et al., “Influence of noninvasive positive pressure ventilation on inspiratory muscle activity in obese subjects,” European Respiratory Journal, vol. 10, no. 12, pp. 2847–2852, 1997. View at Publisher · View at Google Scholar · View at Scopus
  34. C. E. Sullivan, F. G. Issa, M. Berthon-Jones, and L. Eves, “Reversal of obstructive sleep apnoea by continuous positive airway pressure applied through the nares,” The Lancet, vol. 1, no. 8225, pp. 862–865, 1981. View at Google Scholar · View at Scopus
  35. D. M. Rapoport, B. Sorkin, S. M. Garay, and R. M. Goldring, “Reversal of the 'Pickwickian syndrome' by long-term use of nocturnal nasal-airway pressure,” The New England Journal of Medicine, vol. 307, no. 15, pp. 931–933, 1982. View at Google Scholar · View at Scopus
  36. B. Mokhlesi, A. Tulaimat, A. T. Evans et al., “Impact of adherence with positive airway pressure therapy on hypercapnia in obstructive sleep apnea,” Journal of Clinical Sleep Medicine, vol. 2, no. 1, pp. 57–62, 2006. View at Google Scholar · View at Scopus
  37. A. J. Piper, D. Wang, B. J. Yee, D. J. Barnes, and R. R. Grunstein, “Randomised trial of CPAP vs bilevel support in the treatment of obesity hypoventilation syndrome without severe nocturnal desaturation,” Thorax, vol. 63, no. 5, pp. 395–401, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. W. Hida, S. Okabe, K. Tatsumi et al., “Nasal continuous positive airway pressure improves quality of life in obesity hypoventilation syndrome,” Sleep and Breathing, vol. 7, no. 1, pp. 3–12, 2003. View at Publisher · View at Google Scholar · View at Scopus
  39. D. Banerjee, B. J. Yee, A. J. Piper, C. W. Zwillich, and R. R. Grunstein, “Obesity hypoventilation syndrome: Hypoxemia during continuous positive airway pressure,” Chest, vol. 131, no. 6, pp. 1678–1684, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. L. A. Pérez De Llano, R. Golpe, M. Ortiz Piquer et al., “Clinical heterogeneity among patients with obesity hypoventilation syndrome: therapeutic implications,” Respiration, vol. 75, no. 1, pp. 34–39, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. U. Shivaram, M. E. Cash, and A. Beal, “Nasal continuous positive airway pressure in decompensated hypercapnic respiratory failure as a complication of sleep apnea,” Chest, vol. 104, no. 3, pp. 770–774, 1993. View at Google Scholar · View at Scopus
  42. R. B. Berry, A. Chediak, L. K. Brown et al., “Best clinical practices for the sleep center adjustment of noninvasive positive pressure ventilation (NPPV) in stable chronic alveolar hypoventilation syndromes: NPPV Titration Task Force of The American Academy of Sleep Medicine,” Journal of Clinical Sleep Medicine, vol. 6, no. 5, pp. 491–509, 2010. View at Google Scholar · View at Scopus
  43. J. F. Masa, B. R. Celli, J. A. Riesco, M. Hernández, J. Sánchez de Cos, and C. Disdier, “The obesity hypoventilation syndrome can be treated with noninvasive mechanical ventilation,” Chest, vol. 119, no. 4, pp. 1102–1107, 2001. View at Publisher · View at Google Scholar · View at Scopus
  44. P. Priou, J. F. Hamel, C. Person et al., “Long-term outcome of noninvasive positive pressure ventilation for obesity hypoventilation syndrome,” Chest, vol. 138, no. 1, pp. 84–90, 2010. View at Publisher · View at Google Scholar · View at Scopus
  45. P. de Lucas-Ramos, J. de Miguel-Díez, A. Santacruz-Siminiani, J. M. R. González-Moro, M. J. Buendía-García, and J. L. Izquierdo-Alonso, “Benefits at 1 year of nocturnal intermittent positive pressure ventilation in patients with obesity-hypoventilation syndrome,” Respiratory Medicine, vol. 98, no. 10, pp. 961–967, 2004. View at Publisher · View at Google Scholar · View at Scopus
  46. F. Heinemann, S. Budweiser, J. Dobroschke, and M. Pfeifer, “Non-invasive positive pressure ventilation improves lung volumes in the obesity hypoventilation syndrome,” Respiratory Medicine, vol. 101, no. 6, pp. 1229–1235, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. J. H. Storre, B. Seuthe, R. Fiechter et al., “Average volume-assured pressure support in obesity hypoventilation: a randomized crossover trial,” Chest, vol. 130, no. 3, pp. 815–821, 2006. View at Publisher · View at Google Scholar · View at Scopus
  48. P. B. Murphy, C. Davidson, M. D. Hind et al., “Volume targeted versus pressure support non-invasive ventilation in patients with super obesity and chronic respiratory failure: a randomised controlled trial,” Thorax, vol. 67, no. 8, pp. 727–734, 2012. View at Google Scholar
  49. J. Borel, R. Tamisier, Ganzalez-Bermejo et al., “Noninvasive ventilation in mild obesity hypoventilation syndrome. A randomized controlled trial,” Chest, vol. 141, pp. 692–702, 2012. View at Google Scholar
  50. J. Gonzalez-Bermejo, C. Perrin, J. P. Janssens et al., “Proposal for a systematic analysis of polygraphy or polysomnography for identifying and scoring abnormal events occurring during non-invasive ventilation,” Thorax, vol. 67, no. 6, pp. 546–552, 2012. View at Publisher · View at Google Scholar · View at Scopus
  51. O. Contal, D. Adler, J. C. Borel et al., “Impact of different back-up respiratory rates on the efficacy of non-invasive positive pressure ventilation in obesity hypoventilation syndrome: a randomized trial,” Chest, 2012, in press. View at Publisher · View at Google Scholar
  52. A. BaHammam, “Acute ventilatory failure complicating obesity hypoventilation: update on a ‘critical care syndrome’,” Current Opinion Pulmonary Disease, vol. 16, pp. 543–551, 2010. View at Google Scholar
  53. J. P. Janssens, M. Metzger, and E. Sforza, “Impact of volume targeting on efficacy of bi-level non-invasive ventilation and sleep in obesity-hypoventilation,” Respiratory Medicine, vol. 103, no. 2, pp. 165–172, 2009. View at Publisher · View at Google Scholar · View at Scopus
  54. P. Raju and C. A. Manthous, “The pathogenesis of respiratory failure: an overview,” Respiratory care clinics of North America, vol. 6, no. 2, pp. 195–212, 2000. View at Google Scholar · View at Scopus
  55. G. J. Criner, K. Brennan, J. M. Travaline, and D. Kreimer, “Efficacy and compliance with noninvasive positive pressure ventilation in patients with chronic respiratory failure,” Chest, vol. 116, no. 3, pp. 667–675, 1999. View at Publisher · View at Google Scholar · View at Scopus
  56. R. Moudgil, E. D. Michelakis, and S. L. Archer, “Hypoxic pulmonary vasoconstriction,” Journal of Applied Physiology, vol. 98, no. 1, pp. 390–403, 2005. View at Publisher · View at Google Scholar · View at Scopus
  57. M. A. Alpert and M. W. Hashimi, “Obesity and the heart,” American Journal of the Medical Sciences, vol. 306, no. 2, pp. 117–123, 1993. View at Google Scholar · View at Scopus