Do We Need Exercise Tests to Detect Gas Exchange Impairment in Fibrotic Idiopathic Interstitial Pneumonias?
Table 4
Rest and exercise parameters as a function of disease severity defined by DLco%: mild: DLco ≥ 60%, moderate: DLco < 60% and ≥40% and severe (advanced disease): DLco < 40% [7].
Disease severity
Mild
Moderate
Severe
Parameter
Dlco ≥ 60%
40% ≤ DLco < 60%
DLco < 40%
n = 10
n = 65
n = 46
FVC
99 20
77 11*
69 16$**
FEV1
99 19
81 12*
70 16$£
TLC
89 13
70 11*
66 16$
PaO2, rest (mmHg)
89 6.4
80 9*
69 13.7$**
PaO2, peak (mmHg)
78.7 9
59 10*
51 11$**
P(A-a)O2, rest (mmHg)
22 9
27 9.8
38 13$**
P(A-a)O2, peak (mmHg)
40 7
57 12*
64 12$£
ΔP(A-a)O2/ΔVO2 (mmHg/L)
14.8 11
31 12.5*
44 18$**
Walt test, nadir SaO2 (%)
92 3
87 4*
83 6$**
Walk test, ΔSaO2 (%)
4.3 2.4
8.4 3.8*
11.5 5.2$**
Significantly different from group moderate £P < 0.001, **P < 0.01. Significantly different from group mild $P < 0.001, *P < 0.01.
