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Pulmonary Medicine
Volume 2012, Article ID 818971, 6 pages
http://dx.doi.org/10.1155/2012/818971
Clinical Study

Persistent Pulmonary Hypertension of Non Cardiac Cause in a Neonatal Intensive Care Unit

1Division of Neonatology, Department of Pediatrics, Hospital de São João EPE, Faculty of Medicine of Porto University, 4202-451 Porto, Portugal
2Division of Pediatric Cardiology, Department of Pediatrics, Hospital de São João EPE, Faculty of Medicine of Porto University, 4202-451 Porto, Portugal

Received 24 November 2011; Accepted 22 February 2012

Academic Editor: Despina Papakosta

Copyright © 2012 Gustavo Rocha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Parenchymal lung diseases are the main cause of persistent pulmonary hypertension of the newborn (PPHN). We aimed to assess the non cardiac conditions associated to PPHN in the newborn and the survival rate over the last 15 years, at our center. A retrospective chart review of the neonates admitted for PPHN from 1996 to 2010 was performed. New therapies were introduced in 2003, and the survival rates between two periods (1996–2002 and 2003–2010) were compared. Out of 6750 newborns, 78 (1.1%) had the diagnosis of PPHN of non cardiac cause. The most prevalent causes were associated to pulmonary hypoplasia (30.7%), infection (24.3%), and aspiration syndromes (15.3%). Many other causes were identified in 33.3%. The overall survival rate was 68%. There was a significant difference on survival rates between the two periods (1996–2002 = 63.8% and 2003–2010 = 71.4%, 𝑃 = 0 . 0 4 ). Our study showed a myriad of non cardiac aetiologies for PPHN of the newborn, most of them related to lung disease or lung hypoplasia. We observed an improvement in survival rate since 2003, which was associated to the use of new therapies.