Time course changes in peak expiratory flow rate (PEFR) in asthmatic patients () before acute asthma exacerbations (baseline) and after treatment with oral glucocorticoids. : the start of treatment of acute asthma exacerbations with oral glucocorticoids. Means and ranges are indicated by open circles with bars. Significant differences from baseline are indicated by **. Significant differences from acute asthma exacerbations are indicated by + and ++. (Cited from [19]).