TY - JOUR A2 - Strange, Charlie AU - Sisson, Joseph H. AU - Wyatt, Todd A. AU - Pavlik, Jacqueline A. AU - Sarna, Pawanjit S. AU - Murphy, Peter J. PY - 2013 DA - 2013/11/21 TI - Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism SP - 291375 VL - 2013 AB - Background. Vest chest physiotherapy (VCPT) enhances airway clearance in cystic fibrosis (CF) by an unknown mechanism. Because cilia are sensitive to nitric oxide (NO), we hypothesized that VCPT enhances clearance by changing NO metabolism. Methods. Both normal subjects and stable CF subjects had pre- and post-VCPT airway clearance assessed using nasal saccharin transit time (NSTT) followed by a collection of exhaled breath condensate (EBC) analyzed for NO metabolites (NOx). Results. VCPT shorted NSTT by 35% in normal and stable CF subjects with no difference observed between the groups. EBC NOx concentrations decreased 68% in control subjects after VCPT (before = 115 ± 32 μM versus after = 37 ± 17 μM; P<0.002). CF subjects had a trend toward lower EBC NOx. Conclusion. We found an association between VCPT-stimulated clearance and exhaled NOx levels in human subjects. We speculate that VCPT stimulates clearance via increased NO metabolism. SN - 2090-1836 UR - https://doi.org/10.1155/2013/291375 DO - 10.1155/2013/291375 JF - Pulmonary Medicine PB - Hindawi Publishing Corporation KW - ER -