Review Article

The Relationship between Obstructive Sleep Apnea and Atrial Fibrillation: A Complex Interplay

Table 2

Pathophysiologic mechanisms.

Mechanisms of AF development in obstructive sleep apnea

Negative intrathoracic pressure
Hypoxemia
Hypercapnia
Autonomic nervous system activation
Inflammation
Arterial stiffening
Hypertension
Left ventricular hypertrophy
Diastolic dysfunction
Interventricular septal wall thickening
Left atrial enlargement
Atrial electromechanical remodeling