Table of Contents Author Guidelines Submit a Manuscript
Pulmonary Medicine
Volume 2014, Article ID 329476, 5 pages
Research Article

Association of Serum Magnesium Levels with Frequency of Acute Exacerbations in Chronic Obstructive Pulmonary Disease: A Prospective Study

1Department of Pulmonary Medicine, Recep Tayyip Erdogan University, 53000 Rize, Turkey
2Cardiology Department, Hisar Intercontinental Hospital, 34375 Istanbul, Turkey

Received 26 August 2014; Revised 3 November 2014; Accepted 4 November 2014; Published 18 November 2014

Academic Editor: Charlie Strange

Copyright © 2014 Aziz Gumus et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The course of chronic obstructive pulmonary disease (COPD) is accompanied by acute exacerbations. The purpose of this study is to determine the association of serum magnesium level with acute exacerbations in COPD (COPD-AE). Materials and Methods. Eighty-nine patients hospitalized with COPD-AE were included. Hemogram, biochemical tests, and arterial blood gases were analyzed. Pulmonary function tests were performed in the stable period after discharge. Patients were followed up at 3 monthly periods for one year. Results. Mean age of the patients was (range 47–90) years. Mean number of COPD-AE during follow-up was (range 0–15). On Spearman correlation analysis there were significant negative correlations between number of COPD-AE and predicted FEV1% (), total protein (), globulin (), creatinine (), and uric acid levels (). There were also significant positive correlations between number of COPD-AE and serum magnesium level () and platelet count (). According to linear regression analysis predicted FEV1% (), serum magnesium (), and globulin () levels were independent predictors of number of COPD-AE. Conclusions. In this small prospective observational study we found that serum magnesium level during exacerbation period was the most significant predictor of frequency of COPD-AE.