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Pulmonary Medicine
Volume 2015 (2015), Article ID 416179, 6 pages
http://dx.doi.org/10.1155/2015/416179
Research Article

Clinical Investigation of Benign Asbestos Pleural Effusion

1Department of Medical Oncology, Okayama Rosai Hospital, 1-10-25 Chikkomidorimachi, Okayama 7028055, Japan
2Department of Respiratory Medicine, Okayama Rosai Hospital, 1-10-25 Chikkomidorimachi, Okayama 7028055, Japan
3Department of Respiratory Medicine, Chugoku Chuo Hospital, Fukuyama 7200001, Japan
4Department of Medical Oncology, Yamaguchi-Ube Medical Center, 685 Higashikiwa, Ube 7550241, Japan
5Department of Radiology, Okayama University Hospital, 2-5-1 Shikatacho, Okayama 7008558, Japan
6Department of Diagnostic Radiology 2, Kawasaki Medical School, Okayama 7008505, Japan
7Department of Respiratory Medicine, Asahi Rosai Hospital, 61 Hirakochokita, Owariasahi 4880875, Japan
8Department of Respiratory Medicine, Kobe Rosai Hospital, 4-1-23 Kagoikedori, Chuoku, Kobe 6510053, Japan
9Department of Respiratory Medicine, Toyama Rosai Hospital, 992 Rokuromaru, Uozu 9370042, Japan
10Department of Thoracic Surgery, Chiba Rosai Hospital, 2-16 Tatsumidaihigashi, Ichihara 2900003, Japan
11Department of Internal Medicine, Okayama Rosai Hospital, 1-10-25 Chikkomidorimachi, Okayama 7028055, Japan

Received 17 August 2015; Revised 29 October 2015; Accepted 9 November 2015

Academic Editor: Denis Caillaud

Copyright © 2015 Nobukazu Fujimoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

There is no detailed information about benign asbestos pleural effusion (BAPE). The aim of the study was to clarify the clinical features of BAPE. The criteria of enrolled patients were as follows: (1) history of asbestos exposure; (2) presence of pleural effusion determined by chest X-ray, CT, and thoracentesis; and (3) the absence of other causes of effusion. Clinical information was retrospectively analysed and the radiological images were reviewed. There were 110 BAPE patients between 1991 and 2012. All were males and the median age at diagnosis was 74 years. The median duration of asbestos exposure and period of latency for disease onset of BAPE were 31 and 48 years, respectively. Mean values of hyaluronic acid, adenosine deaminase, and carcinoembryonic antigen in the pleural fluid were 39,840 ng/mL, 23.9 IU/L, and 1.8 ng/mL, respectively. Pleural plaques were detected in 98 cases (89.1%). Asbestosis was present in 6 (5.5%) cases, rounded atelectasis was detected in 41 (37.3%) cases, and diffuse pleural thickening (DPT) was detected in 30 (27.3%) cases. One case developed lung cancer (LC) before and after BAPE. None of the cases developed malignant pleural mesothelioma (MPM) during the follow-up.