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Pulmonary Medicine
Volume 2015 (2015), Article ID 835204, 13 pages
http://dx.doi.org/10.1155/2015/835204
Review Article

Statins in Asthma: Potential Beneficial Effects and Limitations

1Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal 576104, India
2Department of Pulmonary Medicine, Kasturba Medical College, Manipal University, Manipal 576104, India

Received 31 July 2015; Revised 2 October 2015; Accepted 18 October 2015

Academic Editor: Andrew J. Halayko

Copyright © 2015 Dipanjan Bhattacharjee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Asthma’s sustenance as a global pandemic, across centuries, can be attributed to the lack of an understanding of its workings and the inability of the existing treatment modalities to provide a long lasting cure without major adverse effects. The discovery of statins boosted by a better comprehension of the pathophysiology of asthma in the past few decades has opened up a potentially alternative line of treatment that promises to be a big boon for the asthmatics globally. However, the initial excellent results from the preclinical and animal studies have not borne the results in clinical trials that the scientific world was hoping for. In light of this, this review analyzes the ways by which statins could benefit in asthma via their pleiotropic anti-inflammatory properties and explain some of the queries raised in the previous studies and provide recommendations for future studies in this field.