Statins in Asthma: Potential Beneficial Effects and Limitations

Table 1

Summary of retrospective clinical trials and their results used in our review.

Study name	Study type	Statin used	Dose used (mg per day)	Study sample	Statin usage duration	Results; (i) Pulmonary function results; (ii) Airway and serum inflammation; (iii) Asthma symptoms; (iv) Acute exacerbations
Ostroukhova et al. [108]	Retrospective study	—	—	50	2 years	(i) 3% to 5% median worsening of FEV1; (ii) Not measured; (iii) Not measured; (iv) Maintenance medication, nocturnal awakenings, and albuterol use increased
Pagovich et al. [109]	Retrospective study	Atorvastatin, simvastatin	—	70	4 weeks	(i) Pulmonary functions improved; (ii) Not measured; (iii) Not measured; (iv) Not measured
Adams et al. [110]	Retrospective study	—	—	539	Not mentioned	(i) No significant difference; (ii) Not measured; (iii) Not measured; (iv) Not measured
Zeki et al. [111]	Retrospective study	Atorvastatin; Simvastatin; Lovastatin; Pravastatin	—	165	1–5 years	(i) No significant difference; (ii) No significant difference; (iii) Significantly higher ACT score; (iv) No significant difference

RCT: randomized controlled trial. AQLQ: Asthma Quality of Life Questionnaire.
FEV1: forced expiratory volume in 1st second. PEF: peak expiratory flow.
ACQ: Asthma Control Questionnaire. FENO: fractional exhaled nitric oxide.