The Protective Effect of Naringin against Bleomycin-Induced Pulmonary Fibrosis in Wistar Rats

Table 1

Effects of naringin on malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPx) levels in lung tissues of bleomycin, naringin, and control groups.

Groups	MDA (nmol/g protein)	SOD (U/mg protein)	GPx (nmol/min/mg protein)
Control	20.83 ± 10.20	131.50 ± 5.61	10.33 ± 1.63
Bleomycin	65.00 ± 9.57^##	91.83 ± 4.62^##	18.66 ± 4.54^##
Bleomycin + naringin 40	59.30 ± 9.64	99.33 ± 5.50	17.34 ± 2.42
Bleomycin + naringin 80	28.34 ± 7.94	113.83 ± 9.47	12.32 ± 2.65

^##, versus control group; , versus bleomycin group. Data were expressed as “mean ± S.D.” for six rats in each group. Comparisons between the results for four groups were made by using one-way ANOVA followed by Tukey-Kramer multiple comparison tests.