iNOS Inhibition Reduces Lung Mechanical Alterations and Remodeling Induced by Particulate Matter in Mice

Figure 4

Lung remodeling: this figure represents the mean and SEM values of both collagen and elastic fibers content around airways (a) and in alveolar wall (b). The ROFA instillations increased the airway and parenchyma extracellular matrix fibers deposition compared to control, and the iNOS inhibition reduced these responses. p<0.05 compared with saline groups; p<0.05 compared with animals that received ROFA and vehicle treatment.

(a)

(b)