iNOS Inhibition Reduces Lung Mechanical Alterations and Remodeling Induced by Particulate Matter in Mice

Table 3

ROFA-induced oxidative stress: after both five (ROFA-5d) and fifteen instillations (ROFA-15d), mice presented an increase in the number of neutrophils and inflammatory cells that express nNOS and iNOS around airways and in distal lung parenchyma. The macrophages were significantly increased only in ROFA-15d groups compared to saline. P<0.05 compared to saline; #P<0.05 compared to ROFA-5d.

	Airway			Distal lung parenchyma
	iNOS	nNOS	8-iso-PGF2α	iNOS	nNOS	8-iso-PGF2α
SAL	3.3±0.6	3.13±1.20	10.42±0.98	9.30±1.70	10.80±3.20	8.71±1.36
ROFA-5d	44.5±5.0	20.01±3.65	8.73±1.51	33.0±7.4	33,40±5.50	13.53±0.87
ROFA-15d	27.82±3.14,#	10.83±1.9#	20.30±1.51	32.43±5.04	32.40±5.00	15.39±1.05