Diabetes, TZDs, and Bone: A Review of the Clinical Evidence

Schwartz, Ann V.

doi:https://doi.org/10.1155/PPAR/2006/24502

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Volume 2006 | Article ID 024502 | https://doi.org/10.1155/PPAR/2006/24502

Diabetes, TZDs, and Bone: A Review of the Clinical Evidence

Ann V. Schwartz¹

Received01 Apr 2006

Revised07 Jul 2006

Accepted10 Jul 2006

Published19 Sept 2006

Abstract

Evidence from rodent and in vitro models suggests that activation of PPAR-γ by thiazolidinediones (TZDs) causes increased bone marrow adiposity and decreased osteoblastogenesis, resulting in bone loss. TZDs are prescribed for the treatment of diabetes, providing an opportunity to determine whether PPAR-γ activation also impacts bone in humans. In addition, since type 2 diabetes is associated with higher fracture risk, an understanding of the clinical impact of TZDs on bone is needed to guide fracture prevention efforts in this population. This review summarizes current findings regarding type 2 diabetes and increased fracture risk and then considers the available evidence regarding TZD use and bone metabolism in humans.

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Copyright

Copyright © 2006 Ann V. Schwartz. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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