PPAR Gamma Activity and Control of Bone Mass in Skeletal Unloading

Marie, P. J.; Kaabeche, K.

doi:https://doi.org/10.1155/PPAR/2006/64807

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PPARs and Bone Metabolism

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Volume 2006 | Article ID 064807 | https://doi.org/10.1155/PPAR/2006/64807

PPAR Gamma Activity and Control of Bone Mass in Skeletal Unloading

P. J. Marie^1,2and K. Kaabeche^1,2

Received02 May 2006

Revised20 Jun 2006

Accepted05 Jul 2006

Published03 Sept 2006

Abstract

Bone loss occuring with unloading is associated with decreased osteoblastogenesis and increased bone marrow adipogenesis, resulting in bone loss and decreased bone formation. Here, we review the present knowledge on the role of PPARγ in the control of osteoblastogenesis and bone mass in skeletal unloading. We showed that PPARγ positively promotes adipogenesis and negatively regulates osteoblast differentiation of bone marrow stromal cells in unloading, resulting in bone loss. Manipulation of PPARγ2 expression by exogenous TGF-β2 inhibits the exaggerated adipogenesis and corrects the balance between osteoblastogenesis and adipogenesis induced by unloading, leading to prevention of bone loss. This shows that PPARγ plays an important role in the control of bone mass in unloaded bone. Moreover, this opens the possibility that manipulation of PPARγ may correct the balance between osteoblastogenesis and adipogenesis and prevent bone loss, which may have potential implications in the treatment of bone loss in clinical conditions.

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Copyright © 2006 P. J. Marie and K. Kaabeche. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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