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PPAR Research
Volume 2007, Article ID 39654, 10 pages
Review Article

The Functions of PPARs in Aging and Longevity

Department of Internal Medicine, Faculty of Medicine, Celal Bayar University, Manisa 45020, Turkey

Received 5 June 2007; Revised 23 July 2007; Accepted 14 September 2007

Academic Editor: J. Christopher Corton

Copyright © 2007 Adnan Erol. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Peroxisome proliferator-activated receptors (PPARs) are key regulators in various age-associated pathophysiological processes related to energy metabolism and oxidative stress. A progressive rise of oxidative stress and related inflammatory reaction appears the hallmarks of the aging process and many age-related diseases. PPARs are important redox-sensitive transcription factors and their dyregulated activations seem to be major culprits for these pathological processes. Drugs targeting PPARs activity are already in widespread clinical use; however, based on these concepts, this review highlights the understanding of the role of PPARs in aging and indicates the necessary particular attention for the potential therapeutic uses of current PPAR agonists in age-associated diseases.