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PPAR Research
Volume 2008, Article ID 148687, 8 pages
Review Article

Pathophysiological Roles of PPAR 𝜸 in Gastrointestinal Epithelial Cells

Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA

Received 28 March 2008; Accepted 19 May 2008

Academic Editor: Dipak Panigrahy

Copyright © 2008 Brian M. Necela and E. Aubrey Thompson. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although the highest levels of PPAR 𝛾 expression in the body have been reported in the gastrointestinal epithelium, little is known about the physiological functions of that receptor in the gut. Moreover, there is considerable controversy concerning the effects of thiazolidinedione PPAR 𝛾 agonists on the two major diseases of the gastrointestinal track: colorectal cancer and inflammatory bowel disease. We will undertake to review both historical and recently published data with a view toward summarizing what is presently known about the roles of PPAR 𝛾 in both physiological and pathological processes in the gastrointestinal epithelium.