TY - JOUR A2 - Gregoire, Francine M. AU - Wang, Nanping PY - 2008 DA - 2009/01/06 TI - PPAR- in Vascular Pathophysiology SP - 164163 VL - 2008 AB - Peroxisome proliferator-activated receptors belong to the superfamily of ligand-dependent nuclear receptor transcription factors, which include three subtypes: PPAR-α, β/δ, and γ. PPAR-δ, play important roles in the regulation of cell growth and differentiation as well as tissue wound and repair. Emerging evidence has also demonstrated that PPAR-δ is implicated in lipids and glucose metabolism. Most recently, the direct effects of PPAR-δ on cardiovascular processes such as endothelial function and angiogenesis have also been investigated. Therefore, it is suggested that PPAR-δ may have critical roles in cardiovascular pathophysiology and is a potential target for therapeutic intervention of cardiovascular disorders such as atherosclerosis. SN - 1687-4757 UR - https://doi.org/10.1155/2008/164163 DO - 10.1155/2008/164163 JF - PPAR Research PB - Hindawi Publishing Corporation KW - ER -