Roles of PPARγ in the collecting system of the kidney. (a) Expression
of PPARγ is confined to the distal
collecting system (labeled with green) including connective tubules (cn) and
collective ducts (ct). (b) Hematoxylin and esoin stained cross-sections of the
kidney medulla showing numerous collective ducts (ct). (c) Fluorescent PPARγ immunostaining in the
same region of the kidney. (d) Oil red-O stained sections of the distal tubules
(dt) showing severe lipid accumulation in type 2 diabetic (db/db) mice. (e) Summary
of PPARγ functions in the
collective system.
