To Live or to Die: Prosurvival Activity of PPAR𝜸 in Cancers

Table 1

EC₅₀ of common PPAR𝛾 agonists in transactivation assays.

Agonists	Constructs used for transactivation	EC50 (𝝁M)	References
Ciglitazone	mPPAR𝛾1 LBD(a)-GAL4 DBD(b)	3	[5]
Pioglitazone	Wild-type mPPAR𝛾1	0.4	[1]
	Wild-type mPPAR𝛾2	0.4
	mPPAR𝛾1(c) LBD-GAL4 DBD	0.55	[6]
	hPPAR𝛾1(d) LBD-GAL4 DBD	0.58
Rosiglitazone	Wild-type mPPAR𝛾1	0.03	[1]
	Wild-type mPPAR𝛾2	0.1
	mPPAR𝛾1 LBD-GAL4 DBD	0.076	[6]
	hPPAR𝛾1 LBD-GAL4 DBD	0.043
Troglitazone	mPPAR𝛾1 LBD-GAL4 DBD	0.78	[6]
	hPPAR𝛾1 LBD-GAL4 DBD	0.55
15d-PGJ2	Wild-type mPPAR𝛾1	2	[7]
	mPPAR𝛾1 LBD-GAL4 DBD

(a) LBD, ligand binding domain.
(b) DBD, DNA binding domain.
(c) mPPAR𝛾1, mouse PPAR𝛾1.
(d) hPPAR𝛾1, human PPAR𝛾1.